The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c mice
Objective(s):Development of new generation of vaccines against leishmaniasis is possible because long-term protection is usually seen after recovery from cutaneous leishmaniasis. ISCOMATRIX is particulate antigen delivery system composed of antigen, cholesterol, phospholipid and saponin. In this stu...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2016-02-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_6542_1dd12b3e8774326a110ea15e2e6af91b.pdf |
| _version_ | 1819030698761125888 |
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| author | Ahmad Mehravaran Mahmoud Reza Jaafari Seyed Amir Jalali Ali Khamesipour Reza Ranjbar Mansure Hojatizade Ali Badiee |
| author_facet | Ahmad Mehravaran Mahmoud Reza Jaafari Seyed Amir Jalali Ali Khamesipour Reza Ranjbar Mansure Hojatizade Ali Badiee |
| author_sort | Ahmad Mehravaran |
| collection | DOAJ |
| description | Objective(s):Development of new generation of vaccines against leishmaniasis is possible because long-term protection is usually seen after recovery from cutaneous leishmaniasis. ISCOMATRIX is particulate antigen delivery system composed of antigen, cholesterol, phospholipid and saponin. In this study, the role of ISCOMATRIX bilayer composition made by different phase transition temperature (Tc) to induce a type of immune response and protection against leishmaniasis was assessed.
Materials and Methods:ISCOMATRIX formulations with different bilayer compositions consisting of EPC (Tc |
| first_indexed | 2024-12-21T06:34:18Z |
| format | Article |
| id | doaj.art-ad876460a3254e929038759025e1079c |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-21T06:34:18Z |
| publishDate | 2016-02-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-ad876460a3254e929038759025e1079c2022-12-21T19:12:56ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742016-02-011921781866542The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c miceAhmad Mehravaran0Mahmoud Reza Jaafari1Seyed Amir Jalali2Ali Khamesipour3Reza Ranjbar4Mansure Hojatizade5Ali Badiee6Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranBiotechnology Research Center, Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranImmunology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranCenter for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, IranMolecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranNanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranNanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranObjective(s):Development of new generation of vaccines against leishmaniasis is possible because long-term protection is usually seen after recovery from cutaneous leishmaniasis. ISCOMATRIX is particulate antigen delivery system composed of antigen, cholesterol, phospholipid and saponin. In this study, the role of ISCOMATRIX bilayer composition made by different phase transition temperature (Tc) to induce a type of immune response and protection against leishmaniasis was assessed. Materials and Methods:ISCOMATRIX formulations with different bilayer compositions consisting of EPC (Tchttp://ijbms.mums.ac.ir/article_6542_1dd12b3e8774326a110ea15e2e6af91b.pdfImmune responseISCOMATRIXLeishmania majorTransition temperature |
| spellingShingle | Ahmad Mehravaran Mahmoud Reza Jaafari Seyed Amir Jalali Ali Khamesipour Reza Ranjbar Mansure Hojatizade Ali Badiee The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c mice Iranian Journal of Basic Medical Sciences Immune response ISCOMATRIX Leishmania major Transition temperature |
| title | The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c mice |
| title_full | The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c mice |
| title_fullStr | The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c mice |
| title_full_unstemmed | The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c mice |
| title_short | The role of ISCOMATRIX bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in BALB/c mice |
| title_sort | role of iscomatrix bilayer composition to induce a cell mediated immunity and protection against leishmaniasis in balb c mice |
| topic | Immune response ISCOMATRIX Leishmania major Transition temperature |
| url | http://ijbms.mums.ac.ir/article_6542_1dd12b3e8774326a110ea15e2e6af91b.pdf |
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