Genetic Characterizations and Molecular Evolution of VP7 Gene in Human Group A Rotavirus G1
Rotavirus group A (RVA) G1 is one leading genotype circulating in humans worldwide, and related molecular information from a global perspective is still limited. Here, we present a comprehensive description of the genetic characterizations and molecular evolution of the RVA G1 VP7 gene. Our results...
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| Format: | Article |
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MDPI AG
2020-07-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/12/8/831 |
| _version_ | 1797560793546358784 |
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| author | Nan Zhou Lu Zhou Bei Wang |
| author_facet | Nan Zhou Lu Zhou Bei Wang |
| author_sort | Nan Zhou |
| collection | DOAJ |
| description | Rotavirus group A (RVA) G1 is one leading genotype circulating in humans worldwide, and related molecular information from a global perspective is still limited. Here, we present a comprehensive description of the genetic characterizations and molecular evolution of the RVA G1 VP7 gene. Our results show that RVA G1 can be divided into two lineages and multiple sub-lineages with a relatively high genetic diversity. Vaccine strains are phylogenetic, closer to lineage I. The evolutionary rate of the RVA G1 VP7 gene is 8.869 × 10<sup>−4</sup> substitutions/site/year, and its most recent common ancestor was in 1933. The RVA G1 VP7 gene shows a linear evolution at the nucleotide level and a linear accumulation of difference at the amino acid level. Sub-lineage replacement of G1 VP7 gene is also observed and the effective population size of the G1 VP7 gene has had great change in the past decades and has remained stable in recent years. Altogether, the RVA G1 VP7 gene constantly evolves and there is no clear evidence that the evolution of the RVA G1 VP7 gene was influenced by vaccines. Continuous surveillance is still indispensable to evaluate the molecular epidemiology of RVA, especially in the post-vaccination era. |
| first_indexed | 2024-03-10T18:05:28Z |
| format | Article |
| id | doaj.art-ad8897cebb37487995410b494d24386d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T18:05:28Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-ad8897cebb37487995410b494d24386d2023-11-20T08:31:34ZengMDPI AGViruses1999-49152020-07-0112883110.3390/v12080831Genetic Characterizations and Molecular Evolution of VP7 Gene in Human Group A Rotavirus G1Nan Zhou0Lu Zhou1Bei Wang2Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Epidemiology and Statistics, School of Public Health, Southeast University, Nanjing 210009, ChinaDepartment of Acute Infectious Diseases, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Epidemiology and Statistics, School of Public Health, Southeast University, Nanjing 210009, ChinaRotavirus group A (RVA) G1 is one leading genotype circulating in humans worldwide, and related molecular information from a global perspective is still limited. Here, we present a comprehensive description of the genetic characterizations and molecular evolution of the RVA G1 VP7 gene. Our results show that RVA G1 can be divided into two lineages and multiple sub-lineages with a relatively high genetic diversity. Vaccine strains are phylogenetic, closer to lineage I. The evolutionary rate of the RVA G1 VP7 gene is 8.869 × 10<sup>−4</sup> substitutions/site/year, and its most recent common ancestor was in 1933. The RVA G1 VP7 gene shows a linear evolution at the nucleotide level and a linear accumulation of difference at the amino acid level. Sub-lineage replacement of G1 VP7 gene is also observed and the effective population size of the G1 VP7 gene has had great change in the past decades and has remained stable in recent years. Altogether, the RVA G1 VP7 gene constantly evolves and there is no clear evidence that the evolution of the RVA G1 VP7 gene was influenced by vaccines. Continuous surveillance is still indispensable to evaluate the molecular epidemiology of RVA, especially in the post-vaccination era.https://www.mdpi.com/1999-4915/12/8/831human rotavirusG1 genotypeVP7 geneevolution |
| spellingShingle | Nan Zhou Lu Zhou Bei Wang Genetic Characterizations and Molecular Evolution of VP7 Gene in Human Group A Rotavirus G1 Viruses human rotavirus G1 genotype VP7 gene evolution |
| title | Genetic Characterizations and Molecular Evolution of VP7 Gene in Human Group A Rotavirus G1 |
| title_full | Genetic Characterizations and Molecular Evolution of VP7 Gene in Human Group A Rotavirus G1 |
| title_fullStr | Genetic Characterizations and Molecular Evolution of VP7 Gene in Human Group A Rotavirus G1 |
| title_full_unstemmed | Genetic Characterizations and Molecular Evolution of VP7 Gene in Human Group A Rotavirus G1 |
| title_short | Genetic Characterizations and Molecular Evolution of VP7 Gene in Human Group A Rotavirus G1 |
| title_sort | genetic characterizations and molecular evolution of vp7 gene in human group a rotavirus g1 |
| topic | human rotavirus G1 genotype VP7 gene evolution |
| url | https://www.mdpi.com/1999-4915/12/8/831 |
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