Epac: A Promising Therapeutic Target for Vascular Diseases: A Review
Vascular diseases affect the circulatory system and comprise most human diseases. They cause severe symptoms and affect the quality of life of patients. Recently, since their identification, exchange proteins directly activated by cAMP (Epac) have attracted increasing scientific interest, because of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.929152/full |
| _version_ | 1811292316442296320 |
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| author | Yunfeng Pan Yunfeng Pan Yunfeng Pan Jia Liu Jiahui Ren Jiahui Ren Jiahui Ren Yun Luo Yun Luo Yun Luo Xiaobo Sun Xiaobo Sun Xiaobo Sun |
| author_facet | Yunfeng Pan Yunfeng Pan Yunfeng Pan Jia Liu Jiahui Ren Jiahui Ren Jiahui Ren Yun Luo Yun Luo Yun Luo Xiaobo Sun Xiaobo Sun Xiaobo Sun |
| author_sort | Yunfeng Pan |
| collection | DOAJ |
| description | Vascular diseases affect the circulatory system and comprise most human diseases. They cause severe symptoms and affect the quality of life of patients. Recently, since their identification, exchange proteins directly activated by cAMP (Epac) have attracted increasing scientific interest, because of their role in cyclic adenosine monophosphate (cAMP) signaling, a well-known signal transduction pathway. The role of Epac in cardiovascular disease and cancer is extensively studied, whereas their role in kidney disease has not been comprehensively explored yet. In this study, we aimed to review recent studies on the regulatory effects of Epac on various vascular diseases, such as cardiovascular disease, cerebrovascular disease, and cancer. Accumulating evidence has shown that both Epac1 and Epac2 play important roles in vascular diseases under both physiological and pathological conditions. Additionally, there has been an increasing focus on Epac pharmacological modulators. Therefore, we speculated that Epac could serve as a novel therapeutic target for the treatment of vascular diseases. |
| first_indexed | 2024-04-13T04:43:36Z |
| format | Article |
| id | doaj.art-ad8bb0c22e9e4f80aded8fba44511b14 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T04:43:36Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-ad8bb0c22e9e4f80aded8fba44511b142022-12-22T03:01:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-07-011310.3389/fphar.2022.929152929152Epac: A Promising Therapeutic Target for Vascular Diseases: A ReviewYunfeng Pan0Yunfeng Pan1Yunfeng Pan2Jia Liu3Jiahui Ren4Jiahui Ren5Jiahui Ren6Yun Luo7Yun Luo8Yun Luo9Xiaobo Sun10Xiaobo Sun11Xiaobo Sun12Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Efficacy Evaluation of Chinese Medicine Against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Beijing, ChinaGuizhou University of Traditional Chinese Medicine, Guiyang, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Efficacy Evaluation of Chinese Medicine Against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Efficacy Evaluation of Chinese Medicine Against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Beijing, ChinaKey Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBeijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing, ChinaKey Laboratory of Efficacy Evaluation of Chinese Medicine Against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Beijing, ChinaVascular diseases affect the circulatory system and comprise most human diseases. They cause severe symptoms and affect the quality of life of patients. Recently, since their identification, exchange proteins directly activated by cAMP (Epac) have attracted increasing scientific interest, because of their role in cyclic adenosine monophosphate (cAMP) signaling, a well-known signal transduction pathway. The role of Epac in cardiovascular disease and cancer is extensively studied, whereas their role in kidney disease has not been comprehensively explored yet. In this study, we aimed to review recent studies on the regulatory effects of Epac on various vascular diseases, such as cardiovascular disease, cerebrovascular disease, and cancer. Accumulating evidence has shown that both Epac1 and Epac2 play important roles in vascular diseases under both physiological and pathological conditions. Additionally, there has been an increasing focus on Epac pharmacological modulators. Therefore, we speculated that Epac could serve as a novel therapeutic target for the treatment of vascular diseases.https://www.frontiersin.org/articles/10.3389/fphar.2022.929152/fullEpaccAMPvascular diseasetherapeutic targetactivator and inhibitor |
| spellingShingle | Yunfeng Pan Yunfeng Pan Yunfeng Pan Jia Liu Jiahui Ren Jiahui Ren Jiahui Ren Yun Luo Yun Luo Yun Luo Xiaobo Sun Xiaobo Sun Xiaobo Sun Epac: A Promising Therapeutic Target for Vascular Diseases: A Review Frontiers in Pharmacology Epac cAMP vascular disease therapeutic target activator and inhibitor |
| title | Epac: A Promising Therapeutic Target for Vascular Diseases: A Review |
| title_full | Epac: A Promising Therapeutic Target for Vascular Diseases: A Review |
| title_fullStr | Epac: A Promising Therapeutic Target for Vascular Diseases: A Review |
| title_full_unstemmed | Epac: A Promising Therapeutic Target for Vascular Diseases: A Review |
| title_short | Epac: A Promising Therapeutic Target for Vascular Diseases: A Review |
| title_sort | epac a promising therapeutic target for vascular diseases a review |
| topic | Epac cAMP vascular disease therapeutic target activator and inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.929152/full |
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