Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease
Background and objectiveBranch atheromatous disease (BAD) makes patients prone to early neurological deterioration (END), resulting in poor prognosis. The aim of this study was to investigate the association between SUA/SCr and END in BAD stroke patients.MethodsWe conducted a retrospective study tha...
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1098141/full |
| _version_ | 1797946930085494784 |
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| author | Yinglin Liu Honglei Wang Ronghua Xu Lanying He Kun Wu Yao Xu Jian Wang Fan Xu |
| author_facet | Yinglin Liu Honglei Wang Ronghua Xu Lanying He Kun Wu Yao Xu Jian Wang Fan Xu |
| author_sort | Yinglin Liu |
| collection | DOAJ |
| description | Background and objectiveBranch atheromatous disease (BAD) makes patients prone to early neurological deterioration (END), resulting in poor prognosis. The aim of this study was to investigate the association between SUA/SCr and END in BAD stroke patients.MethodsWe conducted a retrospective study that included 241 patients with BAD-stroke within 48 h of symptom onset. We divided the patients into the END group and the no END group. END was defined as an NIHSS score increase of more than 2 points within 1 week. SUA/SCr was calculated by the concentration of serum uric acid and creatine (serum uric acid/serum creatine) on admission. Univariate and multivariate analyses were used to identify independent predictors of END in BAD-stroke patients.ResultsEND was observed in 24.1% (58/241) of the patients in our study. Multiple logistic regression analyses showed that SUA/SCr (aOR, 0.716; 95% CI, 0.538–0.952; P = 0.022) and female sex (aOR, 0.469; 95% CI, 0.245–0.898; P = 0.022) were associated with END after adjusting for confounding factors. The predicted value of SUA/Scr for END was a sensitivity of 79.3%, a specificity of 44.8%, and an AUC of 0.609 (95% CI, 0.527–0.691, P < 0.05). The optimal cut-off value was 4.76.ConclusionSUA/SCr was negatively associated with the risk of END in BAD stroke patients. |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-10T21:19:55Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-ad8d3ccd70664e74929db7c805f0f5db2023-01-20T07:22:29ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-01-011410.3389/fneur.2023.10981411098141Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous diseaseYinglin Liu0Honglei Wang1Ronghua Xu2Lanying He3Kun Wu4Yao Xu5Jian Wang6Fan Xu7Department of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan, ChinaDepartment of Neurology, Yibin Second People's Hospital, Yibin, Sichuan, ChinaDepartment of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan, ChinaDepartment of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan, ChinaDepartment of Laboratory, Yibin Sixth People's Hospital, Yibin, Sichuan, ChinaDepartment of Radiology, Pingshan County People's Hospital, Chengdu, Sichuan, ChinaDepartment of Neurology, Chengdu Second People's Hospital, Chengdu, Sichuan, ChinaDepartment of Public Health, School of Public Health, Chengdu Medical College, Chengdu, Sichuan, ChinaBackground and objectiveBranch atheromatous disease (BAD) makes patients prone to early neurological deterioration (END), resulting in poor prognosis. The aim of this study was to investigate the association between SUA/SCr and END in BAD stroke patients.MethodsWe conducted a retrospective study that included 241 patients with BAD-stroke within 48 h of symptom onset. We divided the patients into the END group and the no END group. END was defined as an NIHSS score increase of more than 2 points within 1 week. SUA/SCr was calculated by the concentration of serum uric acid and creatine (serum uric acid/serum creatine) on admission. Univariate and multivariate analyses were used to identify independent predictors of END in BAD-stroke patients.ResultsEND was observed in 24.1% (58/241) of the patients in our study. Multiple logistic regression analyses showed that SUA/SCr (aOR, 0.716; 95% CI, 0.538–0.952; P = 0.022) and female sex (aOR, 0.469; 95% CI, 0.245–0.898; P = 0.022) were associated with END after adjusting for confounding factors. The predicted value of SUA/Scr for END was a sensitivity of 79.3%, a specificity of 44.8%, and an AUC of 0.609 (95% CI, 0.527–0.691, P < 0.05). The optimal cut-off value was 4.76.ConclusionSUA/SCr was negatively associated with the risk of END in BAD stroke patients.https://www.frontiersin.org/articles/10.3389/fneur.2023.1098141/fullbranch atheromatous diseaseearly neurological deteriorationSUA/SCruric acidprognosis |
| spellingShingle | Yinglin Liu Honglei Wang Ronghua Xu Lanying He Kun Wu Yao Xu Jian Wang Fan Xu Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease Frontiers in Neurology branch atheromatous disease early neurological deterioration SUA/SCr uric acid prognosis |
| title | Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease |
| title_full | Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease |
| title_fullStr | Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease |
| title_full_unstemmed | Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease |
| title_short | Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease |
| title_sort | serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease |
| topic | branch atheromatous disease early neurological deterioration SUA/SCr uric acid prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1098141/full |
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