Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury
Ischemia–reperfusion (I/R) is a common pathological phenomenon that occurs in numerous organs and diseases. It generally results from secondary damage caused by the recovery of blood flow and reoxygenation, followed by ischemia of organ tissues, which is often accompanied by severe cellular damage a...
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MDPI AG
2022-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/22/3653 |
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| author | Linxiang Zhou Shangting Han Jiayu Guo Tao Qiu Jiangqiao Zhou Lei Shen |
| author_facet | Linxiang Zhou Shangting Han Jiayu Guo Tao Qiu Jiangqiao Zhou Lei Shen |
| author_sort | Linxiang Zhou |
| collection | DOAJ |
| description | Ischemia–reperfusion (I/R) is a common pathological phenomenon that occurs in numerous organs and diseases. It generally results from secondary damage caused by the recovery of blood flow and reoxygenation, followed by ischemia of organ tissues, which is often accompanied by severe cellular damage and death. Currently, effective treatments for I/R injury (IRI) are limited. Ferroptosis, a new type of regulated cell death (RCD), is characterized by iron overload and iron-dependent lipid peroxidation. Mounting evidence has indicated a close relationship between ferroptosis and IRI. Ferroptosis plays a significantly detrimental role in the progression of IRI, and targeting ferroptosis may be a promising approach for treatment of IRI. Considering the substantial progress made in the study of ferroptosis in IRI, in this review, we summarize the pathological mechanisms and therapeutic targets of ferroptosis in IRI. |
| first_indexed | 2024-03-09T18:25:38Z |
| format | Article |
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| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T18:25:38Z |
| publishDate | 2022-11-01 |
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| series | Cells |
| spelling | doaj.art-ad8d52e4d23d4a478e4a6c4f219f59f12023-11-24T07:58:52ZengMDPI AGCells2073-44092022-11-011122365310.3390/cells11223653Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion InjuryLinxiang Zhou0Shangting Han1Jiayu Guo2Tao Qiu3Jiangqiao Zhou4Lei Shen5Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, ChinaDepartment of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, ChinaDepartment of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, ChinaDepartment of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, ChinaDepartment of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, ChinaDepartment of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, ChinaIschemia–reperfusion (I/R) is a common pathological phenomenon that occurs in numerous organs and diseases. It generally results from secondary damage caused by the recovery of blood flow and reoxygenation, followed by ischemia of organ tissues, which is often accompanied by severe cellular damage and death. Currently, effective treatments for I/R injury (IRI) are limited. Ferroptosis, a new type of regulated cell death (RCD), is characterized by iron overload and iron-dependent lipid peroxidation. Mounting evidence has indicated a close relationship between ferroptosis and IRI. Ferroptosis plays a significantly detrimental role in the progression of IRI, and targeting ferroptosis may be a promising approach for treatment of IRI. Considering the substantial progress made in the study of ferroptosis in IRI, in this review, we summarize the pathological mechanisms and therapeutic targets of ferroptosis in IRI.https://www.mdpi.com/2073-4409/11/22/3653ischemia–reperfusion injurytreatmentmechanismferroptosislipid peroxidation |
| spellingShingle | Linxiang Zhou Shangting Han Jiayu Guo Tao Qiu Jiangqiao Zhou Lei Shen Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury Cells ischemia–reperfusion injury treatment mechanism ferroptosis lipid peroxidation |
| title | Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury |
| title_full | Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury |
| title_fullStr | Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury |
| title_full_unstemmed | Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury |
| title_short | Ferroptosis—A New Dawn in the Treatment of Organ Ischemia–Reperfusion Injury |
| title_sort | ferroptosis a new dawn in the treatment of organ ischemia reperfusion injury |
| topic | ischemia–reperfusion injury treatment mechanism ferroptosis lipid peroxidation |
| url | https://www.mdpi.com/2073-4409/11/22/3653 |
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