A Case of Long Partial Response to Combination Therapy of Bevacizumab and Capecitabine for Liver Metastases of Rectal Cancer
A 69-year-old female visited our department with a diagnosis of rectosigmoid cancer and multiple hepatic metastases (stage IV). Abdominal CT revealed multiple metastatic lesions in the bilateral lobes of the liver. The primary lesion was considered to be resectable, and high anterior resection of th...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2011-01-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | http://www.karger.com/Article/FullText/323138 |
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| author | Atsushi Kawasaki Kenji Mimatsu Takatsugu Oida Hisao Kanou Youichi Kuboi Nobutada Fukino Kazutoshi Kida Sadao Amano |
| author_facet | Atsushi Kawasaki Kenji Mimatsu Takatsugu Oida Hisao Kanou Youichi Kuboi Nobutada Fukino Kazutoshi Kida Sadao Amano |
| author_sort | Atsushi Kawasaki |
| collection | DOAJ |
| description | A 69-year-old female visited our department with a diagnosis of rectosigmoid cancer and multiple hepatic metastases (stage IV). Abdominal CT revealed multiple metastatic lesions in the bilateral lobes of the liver. The primary lesion was considered to be resectable, and high anterior resection of the rectum was performed. After the operation, 6 courses of therapy with bevacizumab (BV) and modified FOLFOX6 were performed. CT showed a partial response, and tumor marker levels became normal. After a total of 11 courses of this therapy, grade 3 peripheral neuropathy developed, and the therapy was changed to BV and capecitabine (Cape). After 6 courses of this therapy, CT showed the maintenance of partial response, and tumor marker levels were also within the normal range. BV and Cape therapy may be useful not only for reducing peripheral neuropathy, but also as a maintenance therapy in patients requiring the suspension of oxaliplatin administration due to peripheral neuropathy. |
| first_indexed | 2024-04-13T09:55:03Z |
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| id | doaj.art-ad8e26ce4e0b43f4a79b263ffdb9cae4 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-04-13T09:55:03Z |
| publishDate | 2011-01-01 |
| publisher | Karger Publishers |
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| series | Case Reports in Gastroenterology |
| spelling | doaj.art-ad8e26ce4e0b43f4a79b263ffdb9cae42022-12-22T02:51:27ZengKarger PublishersCase Reports in Gastroenterology1662-06312011-01-0151283210.1159/000323138323138A Case of Long Partial Response to Combination Therapy of Bevacizumab and Capecitabine for Liver Metastases of Rectal CancerAtsushi KawasakiKenji MimatsuTakatsugu OidaHisao KanouYouichi KuboiNobutada FukinoKazutoshi KidaSadao AmanoA 69-year-old female visited our department with a diagnosis of rectosigmoid cancer and multiple hepatic metastases (stage IV). Abdominal CT revealed multiple metastatic lesions in the bilateral lobes of the liver. The primary lesion was considered to be resectable, and high anterior resection of the rectum was performed. After the operation, 6 courses of therapy with bevacizumab (BV) and modified FOLFOX6 were performed. CT showed a partial response, and tumor marker levels became normal. After a total of 11 courses of this therapy, grade 3 peripheral neuropathy developed, and the therapy was changed to BV and capecitabine (Cape). After 6 courses of this therapy, CT showed the maintenance of partial response, and tumor marker levels were also within the normal range. BV and Cape therapy may be useful not only for reducing peripheral neuropathy, but also as a maintenance therapy in patients requiring the suspension of oxaliplatin administration due to peripheral neuropathy.http://www.karger.com/Article/FullText/323138OxaliplatinNeuropathyCapecitabineBevacizumabColorectal cancer |
| spellingShingle | Atsushi Kawasaki Kenji Mimatsu Takatsugu Oida Hisao Kanou Youichi Kuboi Nobutada Fukino Kazutoshi Kida Sadao Amano A Case of Long Partial Response to Combination Therapy of Bevacizumab and Capecitabine for Liver Metastases of Rectal Cancer Case Reports in Gastroenterology Oxaliplatin Neuropathy Capecitabine Bevacizumab Colorectal cancer |
| title | A Case of Long Partial Response to Combination Therapy of Bevacizumab and Capecitabine for Liver Metastases of Rectal Cancer |
| title_full | A Case of Long Partial Response to Combination Therapy of Bevacizumab and Capecitabine for Liver Metastases of Rectal Cancer |
| title_fullStr | A Case of Long Partial Response to Combination Therapy of Bevacizumab and Capecitabine for Liver Metastases of Rectal Cancer |
| title_full_unstemmed | A Case of Long Partial Response to Combination Therapy of Bevacizumab and Capecitabine for Liver Metastases of Rectal Cancer |
| title_short | A Case of Long Partial Response to Combination Therapy of Bevacizumab and Capecitabine for Liver Metastases of Rectal Cancer |
| title_sort | case of long partial response to combination therapy of bevacizumab and capecitabine for liver metastases of rectal cancer |
| topic | Oxaliplatin Neuropathy Capecitabine Bevacizumab Colorectal cancer |
| url | http://www.karger.com/Article/FullText/323138 |
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