Era of the 4D animal model
Abstract Revealing the entire dynamics of pathogenesis is critical for understanding, preventing and treating human disease but is limited by systematic clinical sampling. This drawback can be overcome with animal model studies. Recent advances in phenotyping, omics and bioinformatics technologies p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
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| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12306 |
| _version_ | 1797833368506728448 |
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| author | Lihong Zhang Jindan Guo Jiangning Liu |
| author_facet | Lihong Zhang Jindan Guo Jiangning Liu |
| author_sort | Lihong Zhang |
| collection | DOAJ |
| description | Abstract Revealing the entire dynamics of pathogenesis is critical for understanding, preventing and treating human disease but is limited by systematic clinical sampling. This drawback can be overcome with animal model studies. Recent advances in phenotyping, omics and bioinformatics technologies promote the development of the 4D animal model to simulate and digitally display the spatiotemporal landscapes of phenotypes and molecular dynamics in human diseases and reveal novel targets for diagnosis and therapy. In this commentary, the origin, supporting technologies, content, function and application, and advantages of 4D animal models over clinical studies and traditional animal models, as well as their limitations, are presented. |
| first_indexed | 2024-04-09T14:22:02Z |
| format | Article |
| id | doaj.art-ad8fd40855274226a83abaf01433ab1c |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-04-09T14:22:02Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-ad8fd40855274226a83abaf01433ab1c2023-05-04T16:08:00ZengWileyAnimal Models and Experimental Medicine2576-20952023-04-016217818210.1002/ame2.12306Era of the 4D animal modelLihong Zhang0Jindan Guo1Jiangning Liu2NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College Beijing ChinaNHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College Beijing ChinaAbstract Revealing the entire dynamics of pathogenesis is critical for understanding, preventing and treating human disease but is limited by systematic clinical sampling. This drawback can be overcome with animal model studies. Recent advances in phenotyping, omics and bioinformatics technologies promote the development of the 4D animal model to simulate and digitally display the spatiotemporal landscapes of phenotypes and molecular dynamics in human diseases and reveal novel targets for diagnosis and therapy. In this commentary, the origin, supporting technologies, content, function and application, and advantages of 4D animal models over clinical studies and traditional animal models, as well as their limitations, are presented.https://doi.org/10.1002/ame2.12306animal modeldatabasedigitally displayhuman diseasesspatiotemporal landscapes |
| spellingShingle | Lihong Zhang Jindan Guo Jiangning Liu Era of the 4D animal model Animal Models and Experimental Medicine animal model database digitally display human diseases spatiotemporal landscapes |
| title | Era of the 4D animal model |
| title_full | Era of the 4D animal model |
| title_fullStr | Era of the 4D animal model |
| title_full_unstemmed | Era of the 4D animal model |
| title_short | Era of the 4D animal model |
| title_sort | era of the 4d animal model |
| topic | animal model database digitally display human diseases spatiotemporal landscapes |
| url | https://doi.org/10.1002/ame2.12306 |
| work_keys_str_mv | AT lihongzhang eraofthe4danimalmodel AT jindanguo eraofthe4danimalmodel AT jiangningliu eraofthe4danimalmodel |