Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition
Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.984227/full |
| _version_ | 1797937918926389248 |
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| author | Mengzhen Zhou Shi Tang |
| author_facet | Mengzhen Zhou Shi Tang |
| author_sort | Mengzhen Zhou |
| collection | DOAJ |
| description | Orexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in cerebrospinal fluid orexin levels is associated with parallel sleep deterioration. Dual orexin receptor antagonist (DORA) can not only treat the sleep-wakefulness disorder of AD but also improve the performance of patients with cognitive behavior disorder. It is critical to clarify the role of the orexin system in AD, study its relationship with cognitive decline in AD, and evaluate the safety and efficacy of DORA. |
| first_indexed | 2024-04-10T18:51:42Z |
| format | Article |
| id | doaj.art-ad90e487bb024d63a4f164167ed47838 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T18:51:42Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-ad90e487bb024d63a4f164167ed478382023-02-01T07:15:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-02-01910.3389/fmed.2022.984227984227Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognitionMengzhen Zhou0Shi Tang1Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaDepartment of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaOrexin is a neuropeptide produced by the lateral hypothalamus that plays an important role in regulating the sleep-wake cycle. The overexpression of the orexinergic system may be related to the pathology of sleep/wakefulness disorders in Alzheimer's disease (AD). In AD patients, the increase in cerebrospinal fluid orexin levels is associated with parallel sleep deterioration. Dual orexin receptor antagonist (DORA) can not only treat the sleep-wakefulness disorder of AD but also improve the performance of patients with cognitive behavior disorder. It is critical to clarify the role of the orexin system in AD, study its relationship with cognitive decline in AD, and evaluate the safety and efficacy of DORA.https://www.frontiersin.org/articles/10.3389/fmed.2022.984227/fullAlzheimer's diseasecognitioninsomniaorexintreatment |
| spellingShingle | Mengzhen Zhou Shi Tang Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition Frontiers in Medicine Alzheimer's disease cognition insomnia orexin treatment |
| title | Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition |
| title_full | Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition |
| title_fullStr | Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition |
| title_full_unstemmed | Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition |
| title_short | Effect of a dual orexin receptor antagonist on Alzheimer's disease: Sleep disorders and cognition |
| title_sort | effect of a dual orexin receptor antagonist on alzheimer s disease sleep disorders and cognition |
| topic | Alzheimer's disease cognition insomnia orexin treatment |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.984227/full |
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