Exploring clade differentiation of the Faecalibacterium prausnitzii complex
Summary: Faecalibacterium prausnitzii is one of the most prevalent and abundant polyphyletic health-promoting components of the human gut microbiome with a propensity for dysbiotic decreases. To better understand its biology in the human gut, we specifically explored the divergence pressures acting...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222018053 |
| _version_ | 1811189481173155840 |
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| author | Marco Fabbrini Marco Candela Silvia Turroni Patrizia Brigidi Simone Rampelli |
| author_facet | Marco Fabbrini Marco Candela Silvia Turroni Patrizia Brigidi Simone Rampelli |
| author_sort | Marco Fabbrini |
| collection | DOAJ |
| description | Summary: Faecalibacterium prausnitzii is one of the most prevalent and abundant polyphyletic health-promoting components of the human gut microbiome with a propensity for dysbiotic decreases. To better understand its biology in the human gut, we specifically explored the divergence pressures acting on F. prausnitzii clades on a global scale. Five F. prausnitzii clades were de novo identified from 55 publicly available genomes and 92 high-quality metagenome assembled genomes. Divergence rate indices were constructed and validated to compare the divergence rates among the different clades and between each of the diverging genes. For each clade we identified specific patterns of diverging functionalities, probably reflecting different ecological propensities, in term of inter-host dispersion capacity or exploitation of different substrates in the gut environment. Finally, we speculate that these differences may explain, at least in part, the observed differences in the overall divergence rates of F. prausnitzii clades in human populations. |
| first_indexed | 2024-04-11T14:36:30Z |
| format | Article |
| id | doaj.art-ad915fc3e98b4be29ec1565fd4024715 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-11T14:36:30Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-ad915fc3e98b4be29ec1565fd40247152022-12-22T04:18:19ZengElsevieriScience2589-00422022-12-012512105533Exploring clade differentiation of the Faecalibacterium prausnitzii complexMarco Fabbrini0Marco Candela1Silvia Turroni2Patrizia Brigidi3Simone Rampelli4Microbiomics Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna 40138, ItalyUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, ItalyUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, ItalyMicrobiomics Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna 40138, ItalyUnit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, Bologna 40126, Italy; Corresponding authorSummary: Faecalibacterium prausnitzii is one of the most prevalent and abundant polyphyletic health-promoting components of the human gut microbiome with a propensity for dysbiotic decreases. To better understand its biology in the human gut, we specifically explored the divergence pressures acting on F. prausnitzii clades on a global scale. Five F. prausnitzii clades were de novo identified from 55 publicly available genomes and 92 high-quality metagenome assembled genomes. Divergence rate indices were constructed and validated to compare the divergence rates among the different clades and between each of the diverging genes. For each clade we identified specific patterns of diverging functionalities, probably reflecting different ecological propensities, in term of inter-host dispersion capacity or exploitation of different substrates in the gut environment. Finally, we speculate that these differences may explain, at least in part, the observed differences in the overall divergence rates of F. prausnitzii clades in human populations.http://www.sciencedirect.com/science/article/pii/S2589004222018053BacteriologyMicrobial genomicsMicrobiome |
| spellingShingle | Marco Fabbrini Marco Candela Silvia Turroni Patrizia Brigidi Simone Rampelli Exploring clade differentiation of the Faecalibacterium prausnitzii complex iScience Bacteriology Microbial genomics Microbiome |
| title | Exploring clade differentiation of the Faecalibacterium prausnitzii complex |
| title_full | Exploring clade differentiation of the Faecalibacterium prausnitzii complex |
| title_fullStr | Exploring clade differentiation of the Faecalibacterium prausnitzii complex |
| title_full_unstemmed | Exploring clade differentiation of the Faecalibacterium prausnitzii complex |
| title_short | Exploring clade differentiation of the Faecalibacterium prausnitzii complex |
| title_sort | exploring clade differentiation of the faecalibacterium prausnitzii complex |
| topic | Bacteriology Microbial genomics Microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222018053 |
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