Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study
<p>Abstract</p> <p>Background</p> <p>Ovarian stimulation in women with polycystic ovary syndrome (PCOS) increases the risk for perinatal complications. Ovulation induction by laparoscopic ovarian drilling (LOD) might improve the overall pregnancy outcomes. The aim of ou...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2010-05-01
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| Series: | Reproductive Biology and Endocrinology |
| Online Access: | http://www.rbej.com/content/8/1/45 |
| _version_ | 1811298670562246656 |
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| author | Vytiska-Binstorfer Elisabeth Wirth Stefan Nouri Kazem Kurz Christine Ott Johannes Huber Johannes C Mayerhofer Klaus |
| author_facet | Vytiska-Binstorfer Elisabeth Wirth Stefan Nouri Kazem Kurz Christine Ott Johannes Huber Johannes C Mayerhofer Klaus |
| author_sort | Vytiska-Binstorfer Elisabeth |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Ovarian stimulation in women with polycystic ovary syndrome (PCOS) increases the risk for perinatal complications. Ovulation induction by laparoscopic ovarian drilling (LOD) might improve the overall pregnancy outcomes. The aim of our study was to assess the adverse events or effects on pregnancy of LOD and clomiphene citrate (CC) stimulation in patients who received metformin.</p> <p>Methods</p> <p>Setting: Academic research institution. We retrospectively analyzed the courses of 40 spontaneous pregnancies after LOD for CC-resistance, 40 pregnancies after CC stimulation, and 40 pregnancies after metformin treatment alone. Patients in the LOD and the CC groups had been pre-treated with Metformin. Primary outcome parameters were: the rate of multiple pregnancies; the rate of early pregnancy losses/miscarriages; the development of gestational diabetes, pregnancy-induced hypertension, and preeclampsia/HELLP-syndrome; premature delivery; and birth weight.</p> <p>Results</p> <p>The rate of twin pregnancies did not differ between the CC group (12.5%), the LOD group (7.5%), and the metformin only group (2.5%, p = 0.239). Seventeen women suffered an early miscarriage. There were no differences with regard to the rates of gestational diabetes, pregnancy-induced hypertension, preeclampsia, and preterm delivery. By analyzing all pregnancy complications together, the overall pregnancy complication rate was highest in the CC group (70.0%, 28/40), followed by the LOD group (45.0%, 18/40), and the metformin only group (47.5%, 19/40; p = 0.047).</p> <p>Conclusions</p> <p>CC, but not LOD, increases the complication rate in pregnant patients who received metformin.</p> |
| first_indexed | 2024-04-13T06:23:44Z |
| format | Article |
| id | doaj.art-ad925869500b4b0fbb84b9f7f72d5027 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-04-13T06:23:44Z |
| publishDate | 2010-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-ad925869500b4b0fbb84b9f7f72d50272022-12-22T02:58:31ZengBMCReproductive Biology and Endocrinology1477-78272010-05-01814510.1186/1477-7827-8-45Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective studyVytiska-Binstorfer ElisabethWirth StefanNouri KazemKurz ChristineOtt JohannesHuber Johannes CMayerhofer Klaus<p>Abstract</p> <p>Background</p> <p>Ovarian stimulation in women with polycystic ovary syndrome (PCOS) increases the risk for perinatal complications. Ovulation induction by laparoscopic ovarian drilling (LOD) might improve the overall pregnancy outcomes. The aim of our study was to assess the adverse events or effects on pregnancy of LOD and clomiphene citrate (CC) stimulation in patients who received metformin.</p> <p>Methods</p> <p>Setting: Academic research institution. We retrospectively analyzed the courses of 40 spontaneous pregnancies after LOD for CC-resistance, 40 pregnancies after CC stimulation, and 40 pregnancies after metformin treatment alone. Patients in the LOD and the CC groups had been pre-treated with Metformin. Primary outcome parameters were: the rate of multiple pregnancies; the rate of early pregnancy losses/miscarriages; the development of gestational diabetes, pregnancy-induced hypertension, and preeclampsia/HELLP-syndrome; premature delivery; and birth weight.</p> <p>Results</p> <p>The rate of twin pregnancies did not differ between the CC group (12.5%), the LOD group (7.5%), and the metformin only group (2.5%, p = 0.239). Seventeen women suffered an early miscarriage. There were no differences with regard to the rates of gestational diabetes, pregnancy-induced hypertension, preeclampsia, and preterm delivery. By analyzing all pregnancy complications together, the overall pregnancy complication rate was highest in the CC group (70.0%, 28/40), followed by the LOD group (45.0%, 18/40), and the metformin only group (47.5%, 19/40; p = 0.047).</p> <p>Conclusions</p> <p>CC, but not LOD, increases the complication rate in pregnant patients who received metformin.</p>http://www.rbej.com/content/8/1/45 |
| spellingShingle | Vytiska-Binstorfer Elisabeth Wirth Stefan Nouri Kazem Kurz Christine Ott Johannes Huber Johannes C Mayerhofer Klaus Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study Reproductive Biology and Endocrinology |
| title | Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study |
| title_full | Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study |
| title_fullStr | Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study |
| title_full_unstemmed | Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study |
| title_short | Pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre-treated with metformin: a retrospective study |
| title_sort | pregnancy outcome in women with polycystic ovary syndrome comparing the effects of laparoscopic ovarian drilling and clomiphene citrate stimulation in women pre treated with metformin a retrospective study |
| url | http://www.rbej.com/content/8/1/45 |
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