Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity
Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a signaling mechanism that allows cellular adaptation to ER stress by engaging pro-adaptive transcription factors and alleviating protein folding demand. One such transcription factor, X-box binding protein (XBP1)...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-10-01
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| Series: | Cells |
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| Online Access: | http://www.mdpi.com/2073-4409/1/4/738 |
| _version_ | 1797710854090653696 |
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| author | Joseph W. Brewer Andrew E. Byrd |
| author_facet | Joseph W. Brewer Andrew E. Byrd |
| author_sort | Joseph W. Brewer |
| collection | DOAJ |
| description | Stress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a signaling mechanism that allows cellular adaptation to ER stress by engaging pro-adaptive transcription factors and alleviating protein folding demand. One such transcription factor, X-box binding protein (XBP1), originates from the inositol-requiring transmembrane kinase/endoribonuclease 1 (IRE1) UPR stress sensor. XBP1 up-regulates a pool of genes involved in ER protein translocation, protein folding, vesicular trafficking and ER- associated protein degradation. Recent data suggest that the regulation of XBP1 expression and transcriptional activity may be a tissue- and stress-dependent phenomenon. Moreover, the intricacies involved in “fine-tuning” XBP1 activity in various settings are now coming to light. Here, we provide an overview of recent developments in understanding the regulatory mechanisms underlying XBP1 expression and activity and discuss the significance of these new insights. |
| first_indexed | 2024-03-12T06:58:20Z |
| format | Article |
| id | doaj.art-ad9278ff0d31444fb54e8691806a73da |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:58:20Z |
| publishDate | 2012-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ad9278ff0d31444fb54e8691806a73da2023-09-02T23:54:23ZengMDPI AGCells2073-44092012-10-011473875310.3390/cells1040738Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and ActivityJoseph W. BrewerAndrew E. ByrdStress in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a signaling mechanism that allows cellular adaptation to ER stress by engaging pro-adaptive transcription factors and alleviating protein folding demand. One such transcription factor, X-box binding protein (XBP1), originates from the inositol-requiring transmembrane kinase/endoribonuclease 1 (IRE1) UPR stress sensor. XBP1 up-regulates a pool of genes involved in ER protein translocation, protein folding, vesicular trafficking and ER- associated protein degradation. Recent data suggest that the regulation of XBP1 expression and transcriptional activity may be a tissue- and stress-dependent phenomenon. Moreover, the intricacies involved in “fine-tuning” XBP1 activity in various settings are now coming to light. Here, we provide an overview of recent developments in understanding the regulatory mechanisms underlying XBP1 expression and activity and discuss the significance of these new insights.http://www.mdpi.com/2073-4409/1/4/738endoplasmic reticulumendoplasmic reticulum stressunfolded protein responseXBP1 |
| spellingShingle | Joseph W. Brewer Andrew E. Byrd Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity Cells endoplasmic reticulum endoplasmic reticulum stress unfolded protein response XBP1 |
| title | Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity |
| title_full | Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity |
| title_fullStr | Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity |
| title_full_unstemmed | Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity |
| title_short | Intricately Regulated: A Cellular Toolbox for Fine-Tuning XBP1 Expression and Activity |
| title_sort | intricately regulated a cellular toolbox for fine tuning xbp1 expression and activity |
| topic | endoplasmic reticulum endoplasmic reticulum stress unfolded protein response XBP1 |
| url | http://www.mdpi.com/2073-4409/1/4/738 |
| work_keys_str_mv | AT josephwbrewer intricatelyregulatedacellulartoolboxforfinetuningxbp1expressionandactivity AT andrewebyrd intricatelyregulatedacellulartoolboxforfinetuningxbp1expressionandactivity |