Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction
Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30625-9 |
| _version_ | 1811324512097009664 |
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| author | Weijia Sun Shuai Guo Yuheng Li JianWei Li Caizhi Liu Yafei Chen Xuzhao Wang Yingjun Tan Hua Tian Cheng Wang Ruikai Du Guohui Zhong Sai Shi Biao Ma Chang Qu Jingxuan Fu Xiaoyan Jin Dingsheng Zhao Yong Zhan Shukuan Ling Hailong An Yingxian Li |
| author_facet | Weijia Sun Shuai Guo Yuheng Li JianWei Li Caizhi Liu Yafei Chen Xuzhao Wang Yingjun Tan Hua Tian Cheng Wang Ruikai Du Guohui Zhong Sai Shi Biao Ma Chang Qu Jingxuan Fu Xiaoyan Jin Dingsheng Zhao Yong Zhan Shukuan Ling Hailong An Yingxian Li |
| author_sort | Weijia Sun |
| collection | DOAJ |
| description | Osteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction. |
| first_indexed | 2024-04-13T14:15:40Z |
| format | Article |
| id | doaj.art-ad9a828c99b74de39cdca2c41f2000f0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T14:15:40Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ad9a828c99b74de39cdca2c41f2000f02022-12-22T02:43:40ZengNature PortfolioNature Communications2041-17232022-05-0113111510.1038/s41467-022-30625-9Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transductionWeijia Sun0Shuai Guo1Yuheng Li2JianWei Li3Caizhi Liu4Yafei Chen5Xuzhao Wang6Yingjun Tan7Hua Tian8Cheng Wang9Ruikai Du10Guohui Zhong11Sai Shi12Biao Ma13Chang Qu14Jingxuan Fu15Xiaoyan Jin16Dingsheng Zhao17Yong Zhan18Shukuan Ling19Hailong An20Yingxian Li21State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterDepartment of Orthopedics /Engineering Research Center of Bone and Joint Precision Medicine /Beijing Key Laboratory of Spinal Disease Research, Peking University the Third HospitalDepartment of Orthopedics /Engineering Research Center of Bone and Joint Precision Medicine /Beijing Key Laboratory of Spinal Disease Research, Peking University the Third HospitalState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, Hebei University of TechnologyState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training CenterOsteoclast over-activation leads to bone loss and chloride homeostasis is important for osteoclast function. Here, the authors show that Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction.https://doi.org/10.1038/s41467-022-30625-9 |
| spellingShingle | Weijia Sun Shuai Guo Yuheng Li JianWei Li Caizhi Liu Yafei Chen Xuzhao Wang Yingjun Tan Hua Tian Cheng Wang Ruikai Du Guohui Zhong Sai Shi Biao Ma Chang Qu Jingxuan Fu Xiaoyan Jin Dingsheng Zhao Yong Zhan Shukuan Ling Hailong An Yingxian Li Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction Nature Communications |
| title | Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction |
| title_full | Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction |
| title_fullStr | Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction |
| title_full_unstemmed | Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction |
| title_short | Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction |
| title_sort | anoctamin 1 controls bone resorption by coupling cl channel activation with rankl rank signaling transduction |
| url | https://doi.org/10.1038/s41467-022-30625-9 |
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