Comparison of the hemocompatibility of neurovascular flow diverters with anti-thrombogenic coatings
Despite the continual progress in technology, thromboembolic complications still occur following endovascular treatment of cerebral aneurysms and remain the primary contributor to morbidity and mortality. Thus, coating the surfaces of blood-contacting flow diverters may reduce thrombus-related compl...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Journal of Science: Advanced Materials and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468217923001351 |
| _version_ | 1797301408101302272 |
|---|---|
| author | Melis Güler Girbas Tomáš Riedel Zuzana Riedelová Melanie Wolf Christian Schlensak Meltem Avci-Adali |
| author_facet | Melis Güler Girbas Tomáš Riedel Zuzana Riedelová Melanie Wolf Christian Schlensak Meltem Avci-Adali |
| author_sort | Melis Güler Girbas |
| collection | DOAJ |
| description | Despite the continual progress in technology, thromboembolic complications still occur following endovascular treatment of cerebral aneurysms and remain the primary contributor to morbidity and mortality. Thus, coating the surfaces of blood-contacting flow diverters may reduce thrombus-related complications in clinical use. In this study, the hemocompatibility of different commercially available flow diverters Pipeline Flex Embolization Device with Shield Technology (Medtronic), the p64 MW HPC (Phenox), and the DERIVO 2heal (Acandis) was investigated using an in vitro blood circulation model. The DERIVO 2 flow diverter was included in this study as an uncoated device. The markers of coagulation (thrombin-antithrombin complex (TAT)), thrombocytes (β-thromboglobulin (β-TG)), inflammation (PMN elastase), and complement system (SC5b-9, C3a, and C5a) activation were detected by enzyme-linked immunosorbent assay (ELISA). In addition to blood cell counts and hemolysis, thrombogenicity was determined using scanning electron microscopy. Flow diverters with anti-thrombogenic coatings resulted in significantly lower activation of coagulation (TAT) and platelets (β-TG) and lower adhesion of platelets compared with the uncoated DERIVO 2 flow diverter. There were no significant differences between the coated flow diverters in terms of TAT and β-TG levels, as well as platelet adhesion. However, significantly lower activation of the complement system (SC5b-9 and C5a) was observed for the DERIVO 2heal flow diverter in comparison with the Pipeline Flex Shield and the p64 MW HPC flow diverters emphasizing the improved hemocompatibility of the fibrin/heparin-coated DERIVO 2heal flow diverter. |
| first_indexed | 2024-03-07T23:22:06Z |
| format | Article |
| id | doaj.art-ad9a83a7428b459f9deeb1d90f07c7f6 |
| institution | Directory Open Access Journal |
| issn | 2468-2179 |
| language | English |
| last_indexed | 2024-03-07T23:22:06Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Science: Advanced Materials and Devices |
| spelling | doaj.art-ad9a83a7428b459f9deeb1d90f07c7f62024-02-21T05:29:30ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792024-03-0191100666Comparison of the hemocompatibility of neurovascular flow diverters with anti-thrombogenic coatingsMelis Güler Girbas0Tomáš Riedel1Zuzana Riedelová2Melanie Wolf3Christian Schlensak4Meltem Avci-Adali5University Hospital Tuebingen, Department of Thoracic and Cardiovascular Surgery, Calwerstraße 7/1, 72076, Tuebingen, GermanyInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Department of Chemistry and Physics of Surfaces and Biointerfaces, Heyrovského nám. 2, 162 06, Prague 6, Czech RepublicInstitute of Macromolecular Chemistry, Czech Academy of Sciences, Department of Chemistry and Physics of Surfaces and Biointerfaces, Heyrovského nám. 2, 162 06, Prague 6, Czech RepublicUniversity Hospital Tuebingen, Department of Thoracic and Cardiovascular Surgery, Calwerstraße 7/1, 72076, Tuebingen, GermanyUniversity Hospital Tuebingen, Department of Thoracic and Cardiovascular Surgery, Calwerstraße 7/1, 72076, Tuebingen, GermanyUniversity Hospital Tuebingen, Department of Thoracic and Cardiovascular Surgery, Calwerstraße 7/1, 72076, Tuebingen, Germany; Corresponding author. Department of Thoracic and Cardiovascular Surgery, University Hospital Tuebingen, Calwerstr. 7/1, 72076 Tuebingen, Germany.Despite the continual progress in technology, thromboembolic complications still occur following endovascular treatment of cerebral aneurysms and remain the primary contributor to morbidity and mortality. Thus, coating the surfaces of blood-contacting flow diverters may reduce thrombus-related complications in clinical use. In this study, the hemocompatibility of different commercially available flow diverters Pipeline Flex Embolization Device with Shield Technology (Medtronic), the p64 MW HPC (Phenox), and the DERIVO 2heal (Acandis) was investigated using an in vitro blood circulation model. The DERIVO 2 flow diverter was included in this study as an uncoated device. The markers of coagulation (thrombin-antithrombin complex (TAT)), thrombocytes (β-thromboglobulin (β-TG)), inflammation (PMN elastase), and complement system (SC5b-9, C3a, and C5a) activation were detected by enzyme-linked immunosorbent assay (ELISA). In addition to blood cell counts and hemolysis, thrombogenicity was determined using scanning electron microscopy. Flow diverters with anti-thrombogenic coatings resulted in significantly lower activation of coagulation (TAT) and platelets (β-TG) and lower adhesion of platelets compared with the uncoated DERIVO 2 flow diverter. There were no significant differences between the coated flow diverters in terms of TAT and β-TG levels, as well as platelet adhesion. However, significantly lower activation of the complement system (SC5b-9 and C5a) was observed for the DERIVO 2heal flow diverter in comparison with the Pipeline Flex Shield and the p64 MW HPC flow diverters emphasizing the improved hemocompatibility of the fibrin/heparin-coated DERIVO 2heal flow diverter.http://www.sciencedirect.com/science/article/pii/S2468217923001351Intracranial aneurysmsFlow diverterThrombosisHemocompatibility |
| spellingShingle | Melis Güler Girbas Tomáš Riedel Zuzana Riedelová Melanie Wolf Christian Schlensak Meltem Avci-Adali Comparison of the hemocompatibility of neurovascular flow diverters with anti-thrombogenic coatings Journal of Science: Advanced Materials and Devices Intracranial aneurysms Flow diverter Thrombosis Hemocompatibility |
| title | Comparison of the hemocompatibility of neurovascular flow diverters with anti-thrombogenic coatings |
| title_full | Comparison of the hemocompatibility of neurovascular flow diverters with anti-thrombogenic coatings |
| title_fullStr | Comparison of the hemocompatibility of neurovascular flow diverters with anti-thrombogenic coatings |
| title_full_unstemmed | Comparison of the hemocompatibility of neurovascular flow diverters with anti-thrombogenic coatings |
| title_short | Comparison of the hemocompatibility of neurovascular flow diverters with anti-thrombogenic coatings |
| title_sort | comparison of the hemocompatibility of neurovascular flow diverters with anti thrombogenic coatings |
| topic | Intracranial aneurysms Flow diverter Thrombosis Hemocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S2468217923001351 |
| work_keys_str_mv | AT melisgulergirbas comparisonofthehemocompatibilityofneurovascularflowdiverterswithantithrombogeniccoatings AT tomasriedel comparisonofthehemocompatibilityofneurovascularflowdiverterswithantithrombogeniccoatings AT zuzanariedelova comparisonofthehemocompatibilityofneurovascularflowdiverterswithantithrombogeniccoatings AT melaniewolf comparisonofthehemocompatibilityofneurovascularflowdiverterswithantithrombogeniccoatings AT christianschlensak comparisonofthehemocompatibilityofneurovascularflowdiverterswithantithrombogeniccoatings AT meltemavciadali comparisonofthehemocompatibilityofneurovascularflowdiverterswithantithrombogeniccoatings |