Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing
High blood glucose levels, excessive production of reactive oxygen species (ROS), unbalanced inflammatory responses and impaired angiogenesis render chronic wounds more likely to be colonized by bacteria which can form biofilms, leading to recurrent infections and prolonging disunion. The pH-respons...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523001168 |
| _version_ | 1797854006569074688 |
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| author | Shaojie Tan Jiarui Han Xiangnan Yuan Ziyu Song Liheng Gao Jing Gao Lu Wang |
| author_facet | Shaojie Tan Jiarui Han Xiangnan Yuan Ziyu Song Liheng Gao Jing Gao Lu Wang |
| author_sort | Shaojie Tan |
| collection | DOAJ |
| description | High blood glucose levels, excessive production of reactive oxygen species (ROS), unbalanced inflammatory responses and impaired angiogenesis render chronic wounds more likely to be colonized by bacteria which can form biofilms, leading to recurrent infections and prolonging disunion. The pH-responsive fibers of poly (vinyl alcohol) (PVA)/poly (acrylic acid) (PAA) -epigallocatechin gallate (EGCG) have been constructed. The fibers were able to swell (pH > 7.4) /shrink (pH < 6.5) reversibly with changes in wound pH, controlling the rate of drug release and thus dynamically modulating the complex inflammatory environment of the wound. At the phase of bacterial infection (pH = 7–9), the polycarboxylic acid groups in the network ionized, and the dynamic hydrogen bond between EGCG and PVA and PAA was broke, triggered an increased release of EGCG (87.4 %). Thereafter, the EGCG cleared excess ROS (greater than80.0 %) from the wound and showed significant antibacterial activity against S. aureus (98 %) and Pseudomonas aeruginosa (96.7 %), inhibited biofilm formation (74 %). At the proliferative phase, the wound switched to acidic (pH ∼ 6.5). Fibers swelled less and tended to shrink. The release of EGCG was slowed down (45.8 %) to promote macrophage polarization and remodel the wound microenvironment. |
| first_indexed | 2024-04-09T19:58:52Z |
| format | Article |
| id | doaj.art-ad9b4add170e4cc1b9faeb5f2a8e04c6 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-09T19:58:52Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-ad9b4add170e4cc1b9faeb5f2a8e04c62023-04-03T05:20:42ZengElsevierMaterials & Design0264-12752023-03-01227111701Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healingShaojie Tan0Jiarui Han1Xiangnan Yuan2Ziyu Song3Liheng Gao4Jing Gao5Lu Wang6Key Laboratory of Biomedical Textile Materials & Technology in Textile Industry, College of Textiles Donghua University, Shanghai, ChinaKey Laboratory of Biomedical Textile Materials & Technology in Textile Industry, College of Textiles Donghua University, Shanghai, ChinaKey Laboratory of Biomedical Textile Materials & Technology in Textile Industry, College of Textiles Donghua University, Shanghai, ChinaKey Laboratory of Biomedical Textile Materials & Technology in Textile Industry, College of Textiles Donghua University, Shanghai, ChinaKey Laboratory of Biomedical Textile Materials & Technology in Textile Industry, College of Textiles Donghua University, Shanghai, ChinaCorresponding author.; Key Laboratory of Biomedical Textile Materials & Technology in Textile Industry, College of Textiles Donghua University, Shanghai, ChinaKey Laboratory of Biomedical Textile Materials & Technology in Textile Industry, College of Textiles Donghua University, Shanghai, ChinaHigh blood glucose levels, excessive production of reactive oxygen species (ROS), unbalanced inflammatory responses and impaired angiogenesis render chronic wounds more likely to be colonized by bacteria which can form biofilms, leading to recurrent infections and prolonging disunion. The pH-responsive fibers of poly (vinyl alcohol) (PVA)/poly (acrylic acid) (PAA) -epigallocatechin gallate (EGCG) have been constructed. The fibers were able to swell (pH > 7.4) /shrink (pH < 6.5) reversibly with changes in wound pH, controlling the rate of drug release and thus dynamically modulating the complex inflammatory environment of the wound. At the phase of bacterial infection (pH = 7–9), the polycarboxylic acid groups in the network ionized, and the dynamic hydrogen bond between EGCG and PVA and PAA was broke, triggered an increased release of EGCG (87.4 %). Thereafter, the EGCG cleared excess ROS (greater than80.0 %) from the wound and showed significant antibacterial activity against S. aureus (98 %) and Pseudomonas aeruginosa (96.7 %), inhibited biofilm formation (74 %). At the proliferative phase, the wound switched to acidic (pH ∼ 6.5). Fibers swelled less and tended to shrink. The release of EGCG was slowed down (45.8 %) to promote macrophage polarization and remodel the wound microenvironment.http://www.sciencedirect.com/science/article/pii/S0264127523001168ElectrospinningAntioxidant propertypH-responsiveAntibiofilm propertyWound dressing |
| spellingShingle | Shaojie Tan Jiarui Han Xiangnan Yuan Ziyu Song Liheng Gao Jing Gao Lu Wang Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing Materials & Design Electrospinning Antioxidant property pH-responsive Antibiofilm property Wound dressing |
| title | Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing |
| title_full | Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing |
| title_fullStr | Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing |
| title_full_unstemmed | Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing |
| title_short | Epigallocatechin gallate-loaded pH-responsive dressing with effective antioxidant, antibacterial and anti-biofilm properties for wound healing |
| title_sort | epigallocatechin gallate loaded ph responsive dressing with effective antioxidant antibacterial and anti biofilm properties for wound healing |
| topic | Electrospinning Antioxidant property pH-responsive Antibiofilm property Wound dressing |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523001168 |
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