A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital
Absract Background To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. Methods This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | Antimicrobial Resistance and Infection Control |
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| Online Access: | https://doi.org/10.1186/s13756-021-01036-0 |
| _version_ | 1818742183196360704 |
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| author | Vered Schechner Katya Levytskyi Ohad Shalom Alexander Yalek Amos Adler |
| author_facet | Vered Schechner Katya Levytskyi Ohad Shalom Alexander Yalek Amos Adler |
| author_sort | Vered Schechner |
| collection | DOAJ |
| description | Absract Background To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. Methods This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and clinical characteristics of all patients involved in the outbreak. The intervention measures included patients’ cohorting, contact isolation precautions, environmental cleaning and screening of contacts. The molecular features and phylogeny of outbreak-related isolates were studied by whole-genome based analysis. Results The outbreak included 34 patients that were colonized by IMI-Producing E. ludwigii and were identified in 24 wards throughout the hospital. Colonization was identified in the first 72 h of admission in 13/34 patients (38.2%). Most patients (91.2%) were admitted from home and had relatively low level of comorbidities. The majority of them (88%) had no recent use of invasive catheters and none had previous carriage of other multi-drug resistant bacteria. All available isolates harbored the bla IMI-17 allele and belonged to Sequence-Type 385. With the exception of two isolates, all isolates were closely related with less than a 20-SNP difference between them. Conclusions This outbreak had most likely originated in the community and subsequently disseminated inside our institution. More studies are required in order to elucidate the epidemiology of IMI-Producing E. ludwigii and the possible role of environmental sources in its dissemination. |
| first_indexed | 2024-12-18T02:08:28Z |
| format | Article |
| id | doaj.art-ad9d7e5985294d8c91921b60fcca024a |
| institution | Directory Open Access Journal |
| issn | 2047-2994 |
| language | English |
| last_indexed | 2024-12-18T02:08:28Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Antimicrobial Resistance and Infection Control |
| spelling | doaj.art-ad9d7e5985294d8c91921b60fcca024a2022-12-21T21:24:32ZengBMCAntimicrobial Resistance and Infection Control2047-29942021-11-011011710.1186/s13756-021-01036-0A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospitalVered Schechner0Katya Levytskyi1Ohad Shalom2Alexander Yalek3Amos Adler4Section of Epidemiology and Preventative Medicine, Tel-Aviv Sourasky Medical CenterClinical Microbiology Laboratory, Tel-Aviv Sourasky Medical CenterClinical Microbiology Laboratory, Tel-Aviv Sourasky Medical CenterDepartment of Pediatrics, Tel-Aviv Sourasky Medical CenterSackler Faculty of Medicine, Tel-Aviv UniversityAbsract Background To describe the course and intervention of an hospital-wide IMI-Producing Enterobacter ludwigii outbreak. Methods This was an outbreak interventional study, done at a tertiary care center in Tel-Aviv, Israel. Data was collected on the course of the outbreak and the demographic and clinical characteristics of all patients involved in the outbreak. The intervention measures included patients’ cohorting, contact isolation precautions, environmental cleaning and screening of contacts. The molecular features and phylogeny of outbreak-related isolates were studied by whole-genome based analysis. Results The outbreak included 34 patients that were colonized by IMI-Producing E. ludwigii and were identified in 24 wards throughout the hospital. Colonization was identified in the first 72 h of admission in 13/34 patients (38.2%). Most patients (91.2%) were admitted from home and had relatively low level of comorbidities. The majority of them (88%) had no recent use of invasive catheters and none had previous carriage of other multi-drug resistant bacteria. All available isolates harbored the bla IMI-17 allele and belonged to Sequence-Type 385. With the exception of two isolates, all isolates were closely related with less than a 20-SNP difference between them. Conclusions This outbreak had most likely originated in the community and subsequently disseminated inside our institution. More studies are required in order to elucidate the epidemiology of IMI-Producing E. ludwigii and the possible role of environmental sources in its dissemination.https://doi.org/10.1186/s13756-021-01036-0IMIOutbreakCarbapenemase |
| spellingShingle | Vered Schechner Katya Levytskyi Ohad Shalom Alexander Yalek Amos Adler A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital Antimicrobial Resistance and Infection Control IMI Outbreak Carbapenemase |
| title | A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital |
| title_full | A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital |
| title_fullStr | A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital |
| title_full_unstemmed | A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital |
| title_short | A hospital-wide outbreak of IMI-17-producing Enterobacter ludwigii in an Israeli hospital |
| title_sort | hospital wide outbreak of imi 17 producing enterobacter ludwigii in an israeli hospital |
| topic | IMI Outbreak Carbapenemase |
| url | https://doi.org/10.1186/s13756-021-01036-0 |
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