Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes
Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/15/3492 |
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| author | Katarzyna Gałczyńska Zuzanna Drulis-Kawa Michał Arabski |
| author_facet | Katarzyna Gałczyńska Zuzanna Drulis-Kawa Michał Arabski |
| author_sort | Katarzyna Gałczyńska |
| collection | DOAJ |
| description | Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review. |
| first_indexed | 2024-03-10T18:04:28Z |
| format | Article |
| id | doaj.art-ada08fd46a774f7494fc4f80d6383963 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:04:28Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ada08fd46a774f7494fc4f80d63839632023-11-20T08:39:40ZengMDPI AGMolecules1420-30492020-07-012515349210.3390/molecules25153492Antitumor Activity of Pt(II), Ru(III) and Cu(II) ComplexesKatarzyna Gałczyńska0Zuzanna Drulis-Kawa1Michał Arabski2Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, PolandDepartment of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wroclaw, Przybyszewskiego 63-77, 51-148 Wrocław, PolandInstitute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, PolandMetal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review.https://www.mdpi.com/1420-3049/25/15/3492cobaltcopperrutheniumimidazoleapoptosisantitumor activity |
| spellingShingle | Katarzyna Gałczyńska Zuzanna Drulis-Kawa Michał Arabski Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes Molecules cobalt copper ruthenium imidazole apoptosis antitumor activity |
| title | Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes |
| title_full | Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes |
| title_fullStr | Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes |
| title_full_unstemmed | Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes |
| title_short | Antitumor Activity of Pt(II), Ru(III) and Cu(II) Complexes |
| title_sort | antitumor activity of pt ii ru iii and cu ii complexes |
| topic | cobalt copper ruthenium imidazole apoptosis antitumor activity |
| url | https://www.mdpi.com/1420-3049/25/15/3492 |
| work_keys_str_mv | AT katarzynagałczynska antitumoractivityofptiiruiiiandcuiicomplexes AT zuzannadruliskawa antitumoractivityofptiiruiiiandcuiicomplexes AT michałarabski antitumoractivityofptiiruiiiandcuiicomplexes |