A Review on the Molecular Pathology of Epithelial Thyroid Tumors
Epithelial thyroid tumors are all from the thyrocytes, the follicular epithelial cells of the thyroid. If these cells do not replicate the normal mechanisms of growth, cell division, and apoptosis, and enter to the uncontrolled growth phase, thyroid tumors arise. Most of these tumors are benign, but...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2018-10-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/9875 |
| _version_ | 1827839259349876736 |
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| author | Seyedeh Adeleh Razavi Mohammad Hossein Modarressi Parichehreh Yaghmaei Mehdi Hedayati |
| author_facet | Seyedeh Adeleh Razavi Mohammad Hossein Modarressi Parichehreh Yaghmaei Mehdi Hedayati |
| author_sort | Seyedeh Adeleh Razavi |
| collection | DOAJ |
| description | Epithelial thyroid tumors are all from the thyrocytes, the follicular epithelial cells of the thyroid. If these cells do not replicate the normal mechanisms of growth, cell division, and apoptosis, and enter to the uncontrolled growth phase, thyroid tumors arise. Most of these tumors are benign, but some of them are slow-growing malignancies, and a small number of them are also highly-invasive cancers. Failure of the natural mechanisms, and creation a tumor can be due to genetic and epigenetic changes in proto-oncogenes and tumor suppressor genes. Understanding molecular pathology of epithelial thyroid tumors, and recognizing molecular changes of proto-oncogenes and tumor suppressor genes can explain their different clinical features, providing diagnostic and prognostic information, and discovering of the effective treatments. On the other hand, it can provide further research opportunities in the diagnosis, prognosis, and treatment areas. This review article targeted the molecular pathology of epithelial thyroid tumors. |
| first_indexed | 2024-03-12T07:18:26Z |
| format | Article |
| id | doaj.art-ada0c49ee0dd4b9f9702268c996ad2ed |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T07:18:26Z |
| publishDate | 2018-10-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-ada0c49ee0dd4b9f9702268c996ad2ed2023-09-02T22:40:23ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2018-10-013649296497410.22122/jims.v36i492.98753165A Review on the Molecular Pathology of Epithelial Thyroid TumorsSeyedeh Adeleh Razavi0Mohammad Hossein Modarressi1Parichehreh Yaghmaei2Mehdi Hedayati3PhD in Biochemistry, Department of Biology, School of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, IranProfessor, Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, IranProfessor, Department of Biology, School of Basic Sciences, Science and Research Branch, Islamic Azad University, Tehran, IranAssociate Professor, Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, IranEpithelial thyroid tumors are all from the thyrocytes, the follicular epithelial cells of the thyroid. If these cells do not replicate the normal mechanisms of growth, cell division, and apoptosis, and enter to the uncontrolled growth phase, thyroid tumors arise. Most of these tumors are benign, but some of them are slow-growing malignancies, and a small number of them are also highly-invasive cancers. Failure of the natural mechanisms, and creation a tumor can be due to genetic and epigenetic changes in proto-oncogenes and tumor suppressor genes. Understanding molecular pathology of epithelial thyroid tumors, and recognizing molecular changes of proto-oncogenes and tumor suppressor genes can explain their different clinical features, providing diagnostic and prognostic information, and discovering of the effective treatments. On the other hand, it can provide further research opportunities in the diagnosis, prognosis, and treatment areas. This review article targeted the molecular pathology of epithelial thyroid tumors.http://jims.mui.ac.ir/index.php/jims/article/view/9875PathologyMolecularEpithelial tumorThyroidProto-oncogenesTumor suppressor genes |
| spellingShingle | Seyedeh Adeleh Razavi Mohammad Hossein Modarressi Parichehreh Yaghmaei Mehdi Hedayati A Review on the Molecular Pathology of Epithelial Thyroid Tumors مجله دانشکده پزشکی اصفهان Pathology Molecular Epithelial tumor Thyroid Proto-oncogenes Tumor suppressor genes |
| title | A Review on the Molecular Pathology of Epithelial Thyroid Tumors |
| title_full | A Review on the Molecular Pathology of Epithelial Thyroid Tumors |
| title_fullStr | A Review on the Molecular Pathology of Epithelial Thyroid Tumors |
| title_full_unstemmed | A Review on the Molecular Pathology of Epithelial Thyroid Tumors |
| title_short | A Review on the Molecular Pathology of Epithelial Thyroid Tumors |
| title_sort | review on the molecular pathology of epithelial thyroid tumors |
| topic | Pathology Molecular Epithelial tumor Thyroid Proto-oncogenes Tumor suppressor genes |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/9875 |
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