Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation.
Delivery of microbial products into the mammalian cell cytosol by bacterial secretion systems is a strong stimulus for triggering pro-inflammatory host responses. Here we show that Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, tightly regulates expression of the...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-07-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC4081808?pdf=render |
| _version_ | 1819114271138643968 |
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| author | Sebastian E Winter Maria G Winter Victor Poon A Marijke Keestra Torsten Sterzenbach Franziska Faber Luciana F Costa Fabiane Cassou Erica A Costa Geraldo E S Alves Tatiane A Paixão Renato L Santos Andreas J Bäumler |
| author_facet | Sebastian E Winter Maria G Winter Victor Poon A Marijke Keestra Torsten Sterzenbach Franziska Faber Luciana F Costa Fabiane Cassou Erica A Costa Geraldo E S Alves Tatiane A Paixão Renato L Santos Andreas J Bäumler |
| author_sort | Sebastian E Winter |
| collection | DOAJ |
| description | Delivery of microbial products into the mammalian cell cytosol by bacterial secretion systems is a strong stimulus for triggering pro-inflammatory host responses. Here we show that Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, tightly regulates expression of the invasion-associated type III secretion system (T3SS-1) and thus fails to activate these innate immune signaling pathways. The S. Typhi regulatory protein TviA rapidly repressed T3SS-1 expression, thereby preventing RAC1-dependent, RIP2-dependent activation of NF-κB in epithelial cells. Heterologous expression of TviA in S. enterica serovar Typhimurium (S. Typhimurium) suppressed T3SS-1-dependent inflammatory responses generated early after infection in animal models of gastroenteritis. These results suggest that S. Typhi reduces intestinal inflammation by limiting the induction of pathogen-induced processes through regulation of virulence gene expression. |
| first_indexed | 2024-12-22T04:42:38Z |
| format | Article |
| id | doaj.art-ada0d0f3fc74482cbdfd364c340b7514 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-22T04:42:38Z |
| publishDate | 2014-07-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-ada0d0f3fc74482cbdfd364c340b75142022-12-21T18:38:43ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742014-07-01107e100420710.1371/journal.ppat.1004207Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation.Sebastian E WinterMaria G WinterVictor PoonA Marijke KeestraTorsten SterzenbachFranziska FaberLuciana F CostaFabiane CassouErica A CostaGeraldo E S AlvesTatiane A PaixãoRenato L SantosAndreas J BäumlerDelivery of microbial products into the mammalian cell cytosol by bacterial secretion systems is a strong stimulus for triggering pro-inflammatory host responses. Here we show that Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, tightly regulates expression of the invasion-associated type III secretion system (T3SS-1) and thus fails to activate these innate immune signaling pathways. The S. Typhi regulatory protein TviA rapidly repressed T3SS-1 expression, thereby preventing RAC1-dependent, RIP2-dependent activation of NF-κB in epithelial cells. Heterologous expression of TviA in S. enterica serovar Typhimurium (S. Typhimurium) suppressed T3SS-1-dependent inflammatory responses generated early after infection in animal models of gastroenteritis. These results suggest that S. Typhi reduces intestinal inflammation by limiting the induction of pathogen-induced processes through regulation of virulence gene expression.http://europepmc.org/articles/PMC4081808?pdf=render |
| spellingShingle | Sebastian E Winter Maria G Winter Victor Poon A Marijke Keestra Torsten Sterzenbach Franziska Faber Luciana F Costa Fabiane Cassou Erica A Costa Geraldo E S Alves Tatiane A Paixão Renato L Santos Andreas J Bäumler Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation. PLoS Pathogens |
| title | Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation. |
| title_full | Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation. |
| title_fullStr | Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation. |
| title_full_unstemmed | Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation. |
| title_short | Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation. |
| title_sort | salmonella enterica serovar typhi conceals the invasion associated type three secretion system from the innate immune system by gene regulation |
| url | http://europepmc.org/articles/PMC4081808?pdf=render |
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