Prediction of Adverse Drug Reaction Linked to Protein Targets Using Network-Based Information and Machine Learning

Prediction of Adverse Drug Reaction Linked to Protein Targets Using Network-Based Information and Machine Learning

Drug discovery attrition rates, particularly at advanced clinical trial stages, are high because of unexpected adverse drug reactions (ADR) elicited by novel drug candidates. Predicting undesirable ADRs produced by the modulation of certain protein targets would contribute to developing safer drugs,...

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Bibliographic Details
Main Authors: Cristiano Galletti, Joaquim Aguirre-Plans, Baldo Oliva, Narcis Fernandez-Fuentes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Bioinformatics
Subjects:
network biology
drug adverse reaction
drug target
machine learning
protein-adverse reaction association
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2022.906644/full

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