Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population
Introduction: Coronary artery disease (CAD) is the leading health complication worldwide because of its high prevalence and mortality. The association between CAD susceptibility and the rs599839 (C/T) polymorphism in the human proline and serine-rich coiled-coil (PSRC1) was reported in a genome-wide...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2023-09-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
| Subjects: | |
| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-15-168.pdf |
| _version_ | 1797404327241842688 |
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| author | Golnaz Houshmand Mohammad Javad Alemzadeh-Ansari Saeideh Mazloumzadeh Niloofar Naderi Maryam Pourirahim Katayoun Heshmatzad Majid Maleki Samira Kalayinia |
| author_facet | Golnaz Houshmand Mohammad Javad Alemzadeh-Ansari Saeideh Mazloumzadeh Niloofar Naderi Maryam Pourirahim Katayoun Heshmatzad Majid Maleki Samira Kalayinia |
| author_sort | Golnaz Houshmand |
| collection | DOAJ |
| description | Introduction: Coronary artery disease (CAD) is the leading health complication worldwide because of its high prevalence and mortality. The association between CAD susceptibility and the rs599839 (C/T) polymorphism in the human proline and serine-rich coiled-coil (PSRC1) was reported in a genome-wide association study. To validate this association, we performed this case-control study to genotype the 1p13.3 (rs599839) locus in a sample of the Iranian population with CAD (stenosis≥70% in≥1 coronary artery). Methods: We performed an association analysis with PCR and Sanger sequencing of rs599839 (C/T) polymorphism and CAD risk in 280 CAD patients and 287 healthy controls defined as a coronary calcium score of zero and no noncalcified plaques in coronary computed tomography angiography. SPSS, version 16.0, was applied for statistical analysis. Results: The rs599839 (C/T) locus showed a significant association with CAD (P value<0.001). TT and CT genotypes were associated with CAD (P value<0.001). Furthermore, the dominant status (TT+CT vs. CC) was associated with an increased risk of CAD (OR, 9.14; 95% CI, 3.77 to 22.15; and P value<0.001). Conclusion: The study findings indicate strong evidence for rs599839 (C/T) association with CAD risk. |
| first_indexed | 2024-03-09T02:53:22Z |
| format | Article |
| id | doaj.art-ada3f08363b14d21ac149f14f958e959 |
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| issn | 2008-5117 2008-6830 |
| language | English |
| last_indexed | 2024-03-09T02:53:22Z |
| publishDate | 2023-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj.art-ada3f08363b14d21ac149f14f958e9592023-12-05T08:51:14ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302023-09-0115316817310.34172/jcvtr.2023.31742jcvtr-31742Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian populationGolnaz Houshmand0Mohammad Javad Alemzadeh-Ansari1Saeideh Mazloumzadeh2Niloofar Naderi3Maryam Pourirahim4Katayoun Heshmatzad5Majid Maleki6Samira Kalayinia7Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranCardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranCardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranCardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranRajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranCardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranCardiogenetic Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, IranIntroduction: Coronary artery disease (CAD) is the leading health complication worldwide because of its high prevalence and mortality. The association between CAD susceptibility and the rs599839 (C/T) polymorphism in the human proline and serine-rich coiled-coil (PSRC1) was reported in a genome-wide association study. To validate this association, we performed this case-control study to genotype the 1p13.3 (rs599839) locus in a sample of the Iranian population with CAD (stenosis≥70% in≥1 coronary artery). Methods: We performed an association analysis with PCR and Sanger sequencing of rs599839 (C/T) polymorphism and CAD risk in 280 CAD patients and 287 healthy controls defined as a coronary calcium score of zero and no noncalcified plaques in coronary computed tomography angiography. SPSS, version 16.0, was applied for statistical analysis. Results: The rs599839 (C/T) locus showed a significant association with CAD (P value<0.001). TT and CT genotypes were associated with CAD (P value<0.001). Furthermore, the dominant status (TT+CT vs. CC) was associated with an increased risk of CAD (OR, 9.14; 95% CI, 3.77 to 22.15; and P value<0.001). Conclusion: The study findings indicate strong evidence for rs599839 (C/T) association with CAD risk.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-15-168.pdfcoronary artery diseasepsrc1case-control studypolymorphismrisk factor |
| spellingShingle | Golnaz Houshmand Mohammad Javad Alemzadeh-Ansari Saeideh Mazloumzadeh Niloofar Naderi Maryam Pourirahim Katayoun Heshmatzad Majid Maleki Samira Kalayinia Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population Journal of Cardiovascular and Thoracic Research coronary artery disease psrc1 case-control study polymorphism risk factor |
| title | Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population |
| title_full | Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population |
| title_fullStr | Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population |
| title_full_unstemmed | Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population |
| title_short | Polymorphism of rs599839 in the PSRC1 gene is associated with coronary artery disease in an Iranian population |
| title_sort | polymorphism of rs599839 in the psrc1 gene is associated with coronary artery disease in an iranian population |
| topic | coronary artery disease psrc1 case-control study polymorphism risk factor |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-15-168.pdf |
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