Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure

Anomalous AMPK-regulated angiotensin AT1R expression and SIRT1-mediated mitochondrial biogenesis at RVLM in hypertension programming of offspring to maternal high fructose exposure

Abstract Background Tissue oxidative stress, sympathetic activation and nutrient sensing signals are closely related to adult hypertension of fetal origin, although their interactions in hypertension programming remain unclear. Based on a maternal high-fructose diet (HFD) model of programmed hyperte...

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Bibliographic Details
Main Authors: Yung-Mei Chao, Kay L. H. Wu, Pei-Chia Tsai, You-Lin Tain, Steve Leu, Wei-Chia Lee, Julie Y. H. Chan
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Journal of Biomedical Science
Subjects:
Maternal high fructose
AMP-activated protein kinase
Sirtuins
Angiotensin type 1 receptor
Rostral ventrolateral medulla
Programmed hypertension
Online Access:http://link.springer.com/article/10.1186/s12929-020-00660-z

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