Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis

Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis

Abstract Background Extracellular signal-regulated kinases (ERKs) have been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal cancer. ERK1/2 inhibitor can suppress growth of KRAS-mutant pancreatic tumors by targeting cancer cell. However, no stud...

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Bibliographic Details
Main Authors: Zilong Yan, Kenoki Ohuchida, Shuang Fei, Biao Zheng, Weiyu Guan, Haimin Feng, Shin Kibe, Yohei Ando, Kazuhiro Koikawa, Toshiya Abe, Chika Iwamoto, Koji Shindo, Taiki Moriyama, Kohei Nakata, Yoshihiro Miyasaka, Takao Ohtsuka, Kazuhiro Mizumoto, Makoto Hashizume, Masafumi Nakamura
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ERK1/2
Pancreatic cancer
Cancer–stromal interaction
Pancreatic stellate cell
Cellular senescence
Online Access:http://link.springer.com/article/10.1186/s13046-019-1226-8

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