Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart
Positive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In t...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2001-07-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000500017 |
| _version_ | 1827844729732071424 |
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| author | Moacir Paranhos-Silva Lain C Pontes-de-Carvalho Geraldo G de Sá Oliveira Eliane Góes Nascimento Washington LC dos-Santos |
| author_facet | Moacir Paranhos-Silva Lain C Pontes-de-Carvalho Geraldo G de Sá Oliveira Eliane Góes Nascimento Washington LC dos-Santos |
| author_sort | Moacir Paranhos-Silva |
| collection | DOAJ |
| description | Positive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In this work it is shown that a large proportion of dogs (11 out of 56) examined in an endemic area of leishmaniasis presented induration at the site of injection of a diluent containing thimerosal alone. This clearly demonstrates that thimerosal leads to a high number of false positive skin reactions in dogs and that its use in Montenegro's skin test antigenic preparations should be avoided. |
| first_indexed | 2024-03-12T08:47:04Z |
| format | Article |
| id | doaj.art-ada713effe7b436ca8065c650943307a |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:47:04Z |
| publishDate | 2001-07-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-ada713effe7b436ca8065c650943307a2023-09-02T16:26:09ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602001-07-0196567968110.1590/S0074-02762001000500017Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apartMoacir Paranhos-SilvaLain C Pontes-de-CarvalhoGeraldo G de Sá OliveiraEliane Góes NascimentoWashington LC dos-SantosPositive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In this work it is shown that a large proportion of dogs (11 out of 56) examined in an endemic area of leishmaniasis presented induration at the site of injection of a diluent containing thimerosal alone. This clearly demonstrates that thimerosal leads to a high number of false positive skin reactions in dogs and that its use in Montenegro's skin test antigenic preparations should be avoided.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000500017Montenegro's skin testLeishmaniadelayed type hypersensitivitythimerosalcanine visceral leishmaniasis |
| spellingShingle | Moacir Paranhos-Silva Lain C Pontes-de-Carvalho Geraldo G de Sá Oliveira Eliane Góes Nascimento Washington LC dos-Santos Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart Memorias do Instituto Oswaldo Cruz Montenegro's skin test Leishmania delayed type hypersensitivity thimerosal canine visceral leishmaniasis |
| title | Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart |
| title_full | Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart |
| title_fullStr | Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart |
| title_full_unstemmed | Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart |
| title_short | Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart |
| title_sort | skin reactions to thimerosal and leishmania in dogs from a leishmaniasis endemic area it is better to keep them apart |
| topic | Montenegro's skin test Leishmania delayed type hypersensitivity thimerosal canine visceral leishmaniasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000500017 |
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