Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution Experience
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. We evaluated the immunohistochemical (IHC) expression of p63 and p53 in DLBCL and their significance on overall survival (OS) and progression-free survival (PFS). We conducted a retrospective cohort study of 177 patients wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/2/102 |
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| author | Juan Carlos Alvarez Moreno Hisham F. Bahmad Abed Alhalim Aljamal Ruben Delgado Ali Salami Carolina Guillot Amilcar A. Castellano-Sánchez Ana Maria Medina Vathany Sriganeshan |
| author_facet | Juan Carlos Alvarez Moreno Hisham F. Bahmad Abed Alhalim Aljamal Ruben Delgado Ali Salami Carolina Guillot Amilcar A. Castellano-Sánchez Ana Maria Medina Vathany Sriganeshan |
| author_sort | Juan Carlos Alvarez Moreno |
| collection | DOAJ |
| description | Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. We evaluated the immunohistochemical (IHC) expression of p63 and p53 in DLBCL and their significance on overall survival (OS) and progression-free survival (PFS). We conducted a retrospective cohort study of 177 patients with DLBCL who presented to Mount Sinai Medical Center of Florida (Miami Beach, Florida) between 2010 and 2020. IHC staining for p63 and p53 protein expression was performed. A significant correlation was found between p63 positivity and p53 expression, p53/p63 co-positivity, Ki-67 proliferation index, MYC expression, and MYC/BCL2 double expression. Regardless of the germinal center B-cell like (GCB) subgrouping, there was a trend among p53+ patients to have MYC/BCL2 double expression, positive MYC expression, and lower OS and PFS. A tendency of poor OS was seen in p53<sup>+</sup> patients in the non-GCB, GCB, and double expressors subgroups and poor PFS in p53<sup>+</sup> patients regardless of the subgrouping. In conclusion, our results suggest that p63 and p53 may represent potential additional prognostic biomarkers in DLBCL and may be included in the initial diagnostic work up of patients with DLBCL. |
| first_indexed | 2024-03-11T08:58:09Z |
| format | Article |
| id | doaj.art-adaa1f266c2c41e39ccf55c1417f988b |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-11T08:58:09Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-adaa1f266c2c41e39ccf55c1417f988b2023-11-16T19:57:18ZengMDPI AGCurrent Oncology1198-00521718-77292023-01-013021314133110.3390/curroncol30020102Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution ExperienceJuan Carlos Alvarez Moreno0Hisham F. Bahmad1Abed Alhalim Aljamal2Ruben Delgado3Ali Salami4Carolina Guillot5Amilcar A. Castellano-Sánchez6Ana Maria Medina7Vathany Sriganeshan8Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USADepartment of Internal Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USADepartment of Mathematics, Faculty of Sciences, Lebanese University, Nabatieh 1700, LebanonDepartment of Translational Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USAArkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USADiffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. We evaluated the immunohistochemical (IHC) expression of p63 and p53 in DLBCL and their significance on overall survival (OS) and progression-free survival (PFS). We conducted a retrospective cohort study of 177 patients with DLBCL who presented to Mount Sinai Medical Center of Florida (Miami Beach, Florida) between 2010 and 2020. IHC staining for p63 and p53 protein expression was performed. A significant correlation was found between p63 positivity and p53 expression, p53/p63 co-positivity, Ki-67 proliferation index, MYC expression, and MYC/BCL2 double expression. Regardless of the germinal center B-cell like (GCB) subgrouping, there was a trend among p53+ patients to have MYC/BCL2 double expression, positive MYC expression, and lower OS and PFS. A tendency of poor OS was seen in p53<sup>+</sup> patients in the non-GCB, GCB, and double expressors subgroups and poor PFS in p53<sup>+</sup> patients regardless of the subgrouping. In conclusion, our results suggest that p63 and p53 may represent potential additional prognostic biomarkers in DLBCL and may be included in the initial diagnostic work up of patients with DLBCL.https://www.mdpi.com/1718-7729/30/2/102p63p53Ki-67DLBCLprognosisoverall survival |
| spellingShingle | Juan Carlos Alvarez Moreno Hisham F. Bahmad Abed Alhalim Aljamal Ruben Delgado Ali Salami Carolina Guillot Amilcar A. Castellano-Sánchez Ana Maria Medina Vathany Sriganeshan Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution Experience Current Oncology p63 p53 Ki-67 DLBCL prognosis overall survival |
| title | Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution Experience |
| title_full | Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution Experience |
| title_fullStr | Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution Experience |
| title_full_unstemmed | Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution Experience |
| title_short | Prognostic Significance of p53 and p63 in Diffuse Large B-Cell Lymphoma: A Single-Institution Experience |
| title_sort | prognostic significance of p53 and p63 in diffuse large b cell lymphoma a single institution experience |
| topic | p63 p53 Ki-67 DLBCL prognosis overall survival |
| url | https://www.mdpi.com/1718-7729/30/2/102 |
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