Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation
P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5′-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety of important pathophysiological processes such as the mo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/12/6585 |
| _version_ | 1797486520215535616 |
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| author | Elias Rawish Harald F. Langer |
| author_facet | Elias Rawish Harald F. Langer |
| author_sort | Elias Rawish |
| collection | DOAJ |
| description | P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5′-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety of important pathophysiological processes such as the modulation of cardiovascular physiology, mediation of nociception, platelet and macrophage activation, or neuronal–glial integration. While P2X1 receptor activation is long known to drive platelet aggregation, P2X7 receptor antagonists have recently been reported to inhibit platelet activation. Considering the role of both P2X receptors and platelet-mediated inflammation in neuronal diseases such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and stroke, targeting purinergic receptors may provide a valuable novel therapeutic approach in these diseases. Therefore, the present review illuminates the role of platelets and purinergic signaling in these neurological conditions to evaluate potential translational implications. |
| first_indexed | 2024-03-09T23:35:21Z |
| format | Article |
| id | doaj.art-adaa396dc4ef4af6ada90e22f01a80f3 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:35:21Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-adaa396dc4ef4af6ada90e22f01a80f32023-11-23T17:03:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312658510.3390/ijms23126585Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and ThromboinflammationElias Rawish0Harald F. Langer1Cardioimmunology Group, Medical Clinic II, University Heart Center Lübeck, 23538 Lübeck, GermanyCardioimmunology Group, Medical Clinic II, University Heart Center Lübeck, 23538 Lübeck, GermanyP2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5′-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety of important pathophysiological processes such as the modulation of cardiovascular physiology, mediation of nociception, platelet and macrophage activation, or neuronal–glial integration. While P2X1 receptor activation is long known to drive platelet aggregation, P2X7 receptor antagonists have recently been reported to inhibit platelet activation. Considering the role of both P2X receptors and platelet-mediated inflammation in neuronal diseases such as multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, and stroke, targeting purinergic receptors may provide a valuable novel therapeutic approach in these diseases. Therefore, the present review illuminates the role of platelets and purinergic signaling in these neurological conditions to evaluate potential translational implications.https://www.mdpi.com/1422-0067/23/12/6585inflammationP2X receptorthrombosisplateletsstrokeAlzheimer’s disease |
| spellingShingle | Elias Rawish Harald F. Langer Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation International Journal of Molecular Sciences inflammation P2X receptor thrombosis platelets stroke Alzheimer’s disease |
| title | Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation |
| title_full | Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation |
| title_fullStr | Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation |
| title_full_unstemmed | Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation |
| title_short | Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation |
| title_sort | platelets and the role of p2x receptors in nociception pain neuronal toxicity and thromboinflammation |
| topic | inflammation P2X receptor thrombosis platelets stroke Alzheimer’s disease |
| url | https://www.mdpi.com/1422-0067/23/12/6585 |
| work_keys_str_mv | AT eliasrawish plateletsandtheroleofp2xreceptorsinnociceptionpainneuronaltoxicityandthromboinflammation AT haraldflanger plateletsandtheroleofp2xreceptorsinnociceptionpainneuronaltoxicityandthromboinflammation |