Resistance exercise protects mice from protein-induced fat accretion
Low-protein (LP) diets extend the lifespan of diverse species and are associated with improved metabolic health in both rodents and humans. Paradoxically, many athletes and bodybuilders consume high-protein (HP) diets and protein supplements, yet are both fit and metabolically healthy. Here, we exam...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2023-11-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/91007 |
| _version_ | 1797448348607709184 |
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| author | Michaela E Trautman Leah N Braucher Christian Elliehausen Wenyuan G Zhu Esther Zelenovskiy Madelyn Green Michelle M Sonsalla Chung-Yang Yeh Troy A Hornberger Adam R Konopka Dudley W Lamming |
| author_facet | Michaela E Trautman Leah N Braucher Christian Elliehausen Wenyuan G Zhu Esther Zelenovskiy Madelyn Green Michelle M Sonsalla Chung-Yang Yeh Troy A Hornberger Adam R Konopka Dudley W Lamming |
| author_sort | Michaela E Trautman |
| collection | DOAJ |
| description | Low-protein (LP) diets extend the lifespan of diverse species and are associated with improved metabolic health in both rodents and humans. Paradoxically, many athletes and bodybuilders consume high-protein (HP) diets and protein supplements, yet are both fit and metabolically healthy. Here, we examine this paradox using weight pulling, a validated progressive resistance exercise training regimen, in mice fed either an LP diet or an isocaloric HP diet. We find that despite having lower food consumption than the LP group, HP-fed mice gain significantly more fat mass than LP-fed mice when not exercising, while weight pulling protected HP-fed mice from this excess fat accretion. The HP diet augmented exercise-induced hypertrophy of the forearm flexor complex, and weight pulling ability increased more rapidly in the exercised HP-fed mice. Surprisingly, exercise did not protect from HP-induced changes in glycemic control. Our results confirm that HP diets can augment muscle hypertrophy and accelerate strength gain induced by resistance exercise without negative effects on fat mass, and also demonstrate that LP diets may be advantageous in the sedentary. Our results highlight the need to consider both dietary composition and activity, not simply calories, when taking a precision nutrition approach to health. |
| first_indexed | 2024-03-09T14:09:02Z |
| format | Article |
| id | doaj.art-adabdd7dfb2c47559298a1ba9f7239c7 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-09T14:09:02Z |
| publishDate | 2023-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-adabdd7dfb2c47559298a1ba9f7239c72023-11-29T15:39:00ZengeLife Sciences Publications LtdeLife2050-084X2023-11-011210.7554/eLife.91007Resistance exercise protects mice from protein-induced fat accretionMichaela E Trautman0https://orcid.org/0000-0002-3172-0436Leah N Braucher1Christian Elliehausen2Wenyuan G Zhu3Esther Zelenovskiy4Madelyn Green5Michelle M Sonsalla6Chung-Yang Yeh7Troy A Hornberger8https://orcid.org/0000-0002-2349-1899Adam R Konopka9Dudley W Lamming10https://orcid.org/0000-0002-0079-4467Department of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United States; Nutrition and Metabolism Graduate Program, University of Wisconsin- Madison, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United States; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United States; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United States; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United StatesComparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, United States; School of Veterinary Medicine, University of Wisconsin-Madison, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United States; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, United StatesDepartment of Medicine, University of Wisconsin-Madison, Madison, United States; William S. Middleton Memorial Veterans Hospital, Madison, United States; Nutrition and Metabolism Graduate Program, University of Wisconsin- Madison, Madison, United States; Cellular and Molecular Biology Graduate Program, University of Wisconsin-Madison, Madison, United States; Comparative Biomedical Sciences Graduate Program, University of Wisconsin-Madison, Madison, United States; University of Wisconsin Carbone Cancer Center, Madison, United StatesLow-protein (LP) diets extend the lifespan of diverse species and are associated with improved metabolic health in both rodents and humans. Paradoxically, many athletes and bodybuilders consume high-protein (HP) diets and protein supplements, yet are both fit and metabolically healthy. Here, we examine this paradox using weight pulling, a validated progressive resistance exercise training regimen, in mice fed either an LP diet or an isocaloric HP diet. We find that despite having lower food consumption than the LP group, HP-fed mice gain significantly more fat mass than LP-fed mice when not exercising, while weight pulling protected HP-fed mice from this excess fat accretion. The HP diet augmented exercise-induced hypertrophy of the forearm flexor complex, and weight pulling ability increased more rapidly in the exercised HP-fed mice. Surprisingly, exercise did not protect from HP-induced changes in glycemic control. Our results confirm that HP diets can augment muscle hypertrophy and accelerate strength gain induced by resistance exercise without negative effects on fat mass, and also demonstrate that LP diets may be advantageous in the sedentary. Our results highlight the need to consider both dietary composition and activity, not simply calories, when taking a precision nutrition approach to health.https://elifesciences.org/articles/91007dietary proteinresistance trainingmetabolic healthbody composition |
| spellingShingle | Michaela E Trautman Leah N Braucher Christian Elliehausen Wenyuan G Zhu Esther Zelenovskiy Madelyn Green Michelle M Sonsalla Chung-Yang Yeh Troy A Hornberger Adam R Konopka Dudley W Lamming Resistance exercise protects mice from protein-induced fat accretion eLife dietary protein resistance training metabolic health body composition |
| title | Resistance exercise protects mice from protein-induced fat accretion |
| title_full | Resistance exercise protects mice from protein-induced fat accretion |
| title_fullStr | Resistance exercise protects mice from protein-induced fat accretion |
| title_full_unstemmed | Resistance exercise protects mice from protein-induced fat accretion |
| title_short | Resistance exercise protects mice from protein-induced fat accretion |
| title_sort | resistance exercise protects mice from protein induced fat accretion |
| topic | dietary protein resistance training metabolic health body composition |
| url | https://elifesciences.org/articles/91007 |
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