A biomechanics-based parametrized cardiac end-diastolic pressure–volume relationship for accurate patient-specific calibration and estimation
Abstract A simple power law has been proposed in the pioneering work of Klotz et al. (Am J Physiol Heart Circ Physiol 291(1):H403–H412, 2006) to approximate the end-diastolic pressure–volume relationship of the left cardiac ventricle, with limited inter-individual variability provided the volume is...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38196-5 |
| _version_ | 1797778922878795776 |
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| author | Dominique Chapelle Arthur Le Gall |
| author_facet | Dominique Chapelle Arthur Le Gall |
| author_sort | Dominique Chapelle |
| collection | DOAJ |
| description | Abstract A simple power law has been proposed in the pioneering work of Klotz et al. (Am J Physiol Heart Circ Physiol 291(1):H403–H412, 2006) to approximate the end-diastolic pressure–volume relationship of the left cardiac ventricle, with limited inter-individual variability provided the volume is adequately normalized. Nevertheless, we use here a biomechanical model to investigate the sources of the remaining data dispersion observed in the normalized space, and we show that variations of the parameters of the biomechanical model realistically account for a substantial part of this dispersion. We therefore propose an alternative law based on the biomechanical model that embeds some intrinsic physical parameters, which directly enables personalization capabilities, and paves the way for related estimation approaches. |
| first_indexed | 2024-03-12T23:23:32Z |
| format | Article |
| id | doaj.art-adac8c80a63248bb8c840149188159d2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-12T23:23:32Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-adac8c80a63248bb8c840149188159d22023-07-16T11:17:47ZengNature PortfolioScientific Reports2045-23222023-07-011311910.1038/s41598-023-38196-5A biomechanics-based parametrized cardiac end-diastolic pressure–volume relationship for accurate patient-specific calibration and estimationDominique Chapelle0Arthur Le Gall1InriaInriaAbstract A simple power law has been proposed in the pioneering work of Klotz et al. (Am J Physiol Heart Circ Physiol 291(1):H403–H412, 2006) to approximate the end-diastolic pressure–volume relationship of the left cardiac ventricle, with limited inter-individual variability provided the volume is adequately normalized. Nevertheless, we use here a biomechanical model to investigate the sources of the remaining data dispersion observed in the normalized space, and we show that variations of the parameters of the biomechanical model realistically account for a substantial part of this dispersion. We therefore propose an alternative law based on the biomechanical model that embeds some intrinsic physical parameters, which directly enables personalization capabilities, and paves the way for related estimation approaches.https://doi.org/10.1038/s41598-023-38196-5 |
| spellingShingle | Dominique Chapelle Arthur Le Gall A biomechanics-based parametrized cardiac end-diastolic pressure–volume relationship for accurate patient-specific calibration and estimation Scientific Reports |
| title | A biomechanics-based parametrized cardiac end-diastolic pressure–volume relationship for accurate patient-specific calibration and estimation |
| title_full | A biomechanics-based parametrized cardiac end-diastolic pressure–volume relationship for accurate patient-specific calibration and estimation |
| title_fullStr | A biomechanics-based parametrized cardiac end-diastolic pressure–volume relationship for accurate patient-specific calibration and estimation |
| title_full_unstemmed | A biomechanics-based parametrized cardiac end-diastolic pressure–volume relationship for accurate patient-specific calibration and estimation |
| title_short | A biomechanics-based parametrized cardiac end-diastolic pressure–volume relationship for accurate patient-specific calibration and estimation |
| title_sort | biomechanics based parametrized cardiac end diastolic pressure volume relationship for accurate patient specific calibration and estimation |
| url | https://doi.org/10.1038/s41598-023-38196-5 |
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