Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells

Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells

In the mature central nervous system (CNS), oligodendrocytes (OLs) provide support and insulation to axons thanks to the production of a myelin sheath. During their maturation to myelinating cells, OLs require energy and building blocks for lipids, which implies a great investment of energy fuels an...

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Bibliographic Details
Main Authors: Davide Marangon, Matteo Audano, Silvia Pedretti, Marta Fumagalli, Nico Mitro, Davide Lecca, Donatella Caruso, Maria P. Abbracchio
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
oligodendrocyte progenitor cell
oligodendrocyte
energy metabolism
glycolysis
lactate
myelin lipids
Online Access:https://www.mdpi.com/2073-4409/11/15/2369

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