Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective

Repeated MDA5 Gene Loss in Birds: An Evolutionary Perspective

Two key cytosolic receptors belonging to the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family sense the viral RNA-derived danger signals: RIG-I and melanoma differentiation-associated protein 5 (MDA5). Their activation establishes an antiviral state by downstream signaling that ulti...

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Bibliographic Details
Main Authors: Veronika Krchlíková, Tomáš Hron, Martin Těšický, Tao Li, Jiří Hejnar, Michal Vinkler, Daniel Elleder
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Viruses
Subjects:
avian genome
viral sensors
innate immunity
gene loss
Online Access:https://www.mdpi.com/1999-4915/13/11/2131

Internet

https://www.mdpi.com/1999-4915/13/11/2131

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