Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs

Summary: Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein-coupled receptors (GPCRs) and Ras. Using a combination of X-ray crystallography, hydrogen deuterium exchang...

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Bibliographic Details
Main Authors: Manoj K. Rathinaswamy, Meredith L. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, Noah J. Harris, John T. Evans, Jordan T.B. Stariha, Udit Dalwadi, Kaelin D. Fleming, Harish Ranga-Prasad, Calvin K. Yip, Roger L. Williams, Scott D. Hansen, John E. Burke
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723001833

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