A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast
A 34-year-old woman with a rapidly growing right breast mass visited our hospital. The mass was diagnosed as a right breast cancer (cT3N1M0 stage ⦀A). Her serum leucocyte count and C-reactive protein levels were high, and she had persistent fever. However, serum procalcitonin and β-D-glucan levels w...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2021-08-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/518244 |
| _version_ | 1819109446180143104 |
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| author | Haruna Noda Michiko Yamashita Akari Murakami Kumiko Okujima Kana Takemoto Megumi Takaoka Erina Kusakabe Reina Aoki Kana Taguchi Kanako Nishiyama Riko Kitazawa Yoshiaki Kamei Yasutsugu Takada |
| author_facet | Haruna Noda Michiko Yamashita Akari Murakami Kumiko Okujima Kana Takemoto Megumi Takaoka Erina Kusakabe Reina Aoki Kana Taguchi Kanako Nishiyama Riko Kitazawa Yoshiaki Kamei Yasutsugu Takada |
| author_sort | Haruna Noda |
| collection | DOAJ |
| description | A 34-year-old woman with a rapidly growing right breast mass visited our hospital. The mass was diagnosed as a right breast cancer (cT3N1M0 stage ⦀A). Her serum leucocyte count and C-reactive protein levels were high, and she had persistent fever. However, serum procalcitonin and β-D-glucan levels were normal, and no apparent infection focus was detected, although her serum granulocyte colony-stimulating factor (G-CSF) level was markedly elevated to 42.7 pg/mL. Therefore, a G-CSF-producing breast cancer was suspected. A pathological analysis of the surgical specimen revealed a squamous cell carcinoma of the breast (pT2N0 [i+] M0 stage ∥A). Right mastectomy (with the resection of the pectoralis major muscle), axillary lymph node dissection, and split layer grafting were performed. The leucocyte count and serum G-CSF level decreased on postoperative day (POD) 1 and normalized on POD 6. As adjuvant chemotherapy, 4 cycles of a combination chemotherapy with adriamycin and cyclophosphamide and 12 cycles of weekly paclitaxel were administered. After chemotherapy, the patient also underwent postmastectomy radiotherapy. Currently, 30 months after surgery, the patient is alive and well with neither progression nor distant metastasis. G-CSF-producing breast cancers tend to rapidly grow such as in the current case; thus, surgery should be performed immediately, followed by appropriate adjuvant treatment. |
| first_indexed | 2024-12-22T03:25:57Z |
| format | Article |
| id | doaj.art-adaf1817fe2341b88715f7da32f87003 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-22T03:25:57Z |
| publishDate | 2021-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-adaf1817fe2341b88715f7da32f870032022-12-21T18:40:36ZengKarger PublishersCase Reports in Oncology1662-65752021-08-011421175118110.1159/000518244518244A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the BreastHaruna Noda0Michiko Yamashita1Akari Murakami2Kumiko Okujima3Kana Takemoto4Megumi Takaoka5Erina Kusakabe6Reina Aoki7Kana Taguchi8Kanako Nishiyama9Riko Kitazawa10Yoshiaki Kamei11Yasutsugu Takada12Breast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanDepartment of Molecular Pathology, Ehime University Graduate School of Medicine, Toon, JapanBreast Center, Ehime University Hospital, Toon, JapanDepartment of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University Graduate School of Medicine, Toon, JapanA 34-year-old woman with a rapidly growing right breast mass visited our hospital. The mass was diagnosed as a right breast cancer (cT3N1M0 stage ⦀A). Her serum leucocyte count and C-reactive protein levels were high, and she had persistent fever. However, serum procalcitonin and β-D-glucan levels were normal, and no apparent infection focus was detected, although her serum granulocyte colony-stimulating factor (G-CSF) level was markedly elevated to 42.7 pg/mL. Therefore, a G-CSF-producing breast cancer was suspected. A pathological analysis of the surgical specimen revealed a squamous cell carcinoma of the breast (pT2N0 [i+] M0 stage ∥A). Right mastectomy (with the resection of the pectoralis major muscle), axillary lymph node dissection, and split layer grafting were performed. The leucocyte count and serum G-CSF level decreased on postoperative day (POD) 1 and normalized on POD 6. As adjuvant chemotherapy, 4 cycles of a combination chemotherapy with adriamycin and cyclophosphamide and 12 cycles of weekly paclitaxel were administered. After chemotherapy, the patient also underwent postmastectomy radiotherapy. Currently, 30 months after surgery, the patient is alive and well with neither progression nor distant metastasis. G-CSF-producing breast cancers tend to rapidly grow such as in the current case; thus, surgery should be performed immediately, followed by appropriate adjuvant treatment.https://www.karger.com/Article/FullText/518244granulocyte colony-stimulating factor-producing cancerbreast canceradriamycinpaclitaxel |
| spellingShingle | Haruna Noda Michiko Yamashita Akari Murakami Kumiko Okujima Kana Takemoto Megumi Takaoka Erina Kusakabe Reina Aoki Kana Taguchi Kanako Nishiyama Riko Kitazawa Yoshiaki Kamei Yasutsugu Takada A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast Case Reports in Oncology granulocyte colony-stimulating factor-producing cancer breast cancer adriamycin paclitaxel |
| title | A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast |
| title_full | A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast |
| title_fullStr | A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast |
| title_full_unstemmed | A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast |
| title_short | A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast |
| title_sort | case of a rapidly growing granulocyte colony stimulating factor producing squamous cell carcinoma of the breast |
| topic | granulocyte colony-stimulating factor-producing cancer breast cancer adriamycin paclitaxel |
| url | https://www.karger.com/Article/FullText/518244 |
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