Serum C-C motif ligand 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis
Background: The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11/Eotaxin-1 in postmenopausal osteoporosis. Objective: The scope of this study was to explore t...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2019-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581903353W.pdf |
| _version_ | 1818178378564370432 |
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| author | Wang Wen Huang Ci-You Wang Zhuo-Ping Xu Shan-Shan Qian Tie-Yong Chen Yi-Ding Wu Wei-Guo |
| author_facet | Wang Wen Huang Ci-You Wang Zhuo-Ping Xu Shan-Shan Qian Tie-Yong Chen Yi-Ding Wu Wei-Guo |
| author_sort | Wang Wen |
| collection | DOAJ |
| description | Background: The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11/Eotaxin-1 in postmenopausal osteoporosis. Objective: The scope of this study was to explore the relationship between serum CCL11/Eotaxin-1 concentrations and disease progression of postmenopausal females with osteoporosis. Methods: A total of 83 postmenopausal women diagnosed with osteoporosis were enrolled. Meanwhile, 82 postmenopausal women with normal bone mineral density (BMD) and 85 healthy controls inner child-bearing age were enrolled as control. The Dual-energy X-ray absorptiometry was used to examine the BMDs at the femoral neck, lumbar spine 1-4 and total hip of all participants. Serum CCL11/Eotaxin-1 levels were examined by enzyme-linked immunosorbent assay. We also included inflammation marker interleukin-6 (IL-6) as well as a serum marker of bone resorption C-telopeptide cross-linked collagen type 1 (CTX-1). The Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were recorded to evaluate the clinical severity in POMP females. Results: Serum CCL11/Eotaxin-1 levels were significantly elevated in postmenopausal osteoporotic patients PMOP patients compared with PMNOP and healthy controls. We observed a significant negative correlation of serum CCL11/Eotaxin-1 levels with lumbar spine, femoral neck and total hip BMD. Furthermore, serum CCL11/ Eotaxin-1 concentrations were also positively related to the VAS and ODI scores. Last, serum CCL11/ Eotaxin-1 concentrations were positively associated with IL-6 and CTX-1 levels. These correlations remain significant after adjusting for age and BMI. Multivariate linear regression analysis demonstrated that CCL11/Eotaxin-1 could serve as an independent marker. Conclusions: Serum CCL 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis. Therapeutics targeting CCL11/Eotaxin-1 and its related signalling way to prevent and slow progression of PMOP deserve further study. |
| first_indexed | 2024-12-11T20:47:02Z |
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| id | doaj.art-adaf30bf2603404e820ed773ae6b35ad |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-11T20:47:02Z |
| publishDate | 2019-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-adaf30bf2603404e820ed773ae6b35ad2022-12-22T00:51:21ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662019-01-013833533601452-82581903353WSerum C-C motif ligand 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosisWang Wen0Huang Ci-You1Wang Zhuo-Ping2Xu Shan-Shan3Qian Tie-Yong4Chen Yi-Ding5Wu Wei-Guo6People's Hospital of Nanjing Medical University, Department of Endocrinology, the Affiliated Wuxi No. 2, Wuxi, ChinaPeople's Hospital of Nanjing Medical University, Department of Endocrinology, the Affiliated Wuxi No. 2, Wuxi, ChinaPeople's Hospital of Nanjing Medical University, Department of Endocrinology, the Affiliated Wuxi No. 2, Wuxi, ChinaPeople's Hospital of Nanjing Medical University, Department of Endocrinology, the Affiliated Wuxi No. 2, Wuxi, ChinaPeople's Hospital of Nanjing Medical University, Department of Endocrinology, the Affiliated Wuxi No. 2, Wuxi, ChinaPeople's Hospital of Nanjing Medical University, Department of Endocrinology, the Affiliated Wuxi No. 2, Wuxi, ChinaPeople's Hospital of Nanjing Medical University, Department of Endocrinology, the Affiliated Wuxi No. 2, Wuxi, ChinaBackground: The chemokine C-C motif ligand 11, also known as eotaxin-1, has been identified as a novel mediator of inflammatory bone resorption. However, little is known regarding a potential role for CCL11/Eotaxin-1 in postmenopausal osteoporosis. Objective: The scope of this study was to explore the relationship between serum CCL11/Eotaxin-1 concentrations and disease progression of postmenopausal females with osteoporosis. Methods: A total of 83 postmenopausal women diagnosed with osteoporosis were enrolled. Meanwhile, 82 postmenopausal women with normal bone mineral density (BMD) and 85 healthy controls inner child-bearing age were enrolled as control. The Dual-energy X-ray absorptiometry was used to examine the BMDs at the femoral neck, lumbar spine 1-4 and total hip of all participants. Serum CCL11/Eotaxin-1 levels were examined by enzyme-linked immunosorbent assay. We also included inflammation marker interleukin-6 (IL-6) as well as a serum marker of bone resorption C-telopeptide cross-linked collagen type 1 (CTX-1). The Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were recorded to evaluate the clinical severity in POMP females. Results: Serum CCL11/Eotaxin-1 levels were significantly elevated in postmenopausal osteoporotic patients PMOP patients compared with PMNOP and healthy controls. We observed a significant negative correlation of serum CCL11/Eotaxin-1 levels with lumbar spine, femoral neck and total hip BMD. Furthermore, serum CCL11/ Eotaxin-1 concentrations were also positively related to the VAS and ODI scores. Last, serum CCL11/ Eotaxin-1 concentrations were positively associated with IL-6 and CTX-1 levels. These correlations remain significant after adjusting for age and BMI. Multivariate linear regression analysis demonstrated that CCL11/Eotaxin-1 could serve as an independent marker. Conclusions: Serum CCL 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis. Therapeutics targeting CCL11/Eotaxin-1 and its related signalling way to prevent and slow progression of PMOP deserve further study.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581903353W.pdfchemokine c-c motif chemokine 11eotaxin1postmenopausal osteoporosisdisease severity |
| spellingShingle | Wang Wen Huang Ci-You Wang Zhuo-Ping Xu Shan-Shan Qian Tie-Yong Chen Yi-Ding Wu Wei-Guo Serum C-C motif ligand 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis Journal of Medical Biochemistry chemokine c-c motif chemokine 11 eotaxin1 postmenopausal osteoporosis disease severity |
| title | Serum C-C motif ligand 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis |
| title_full | Serum C-C motif ligand 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis |
| title_fullStr | Serum C-C motif ligand 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis |
| title_full_unstemmed | Serum C-C motif ligand 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis |
| title_short | Serum C-C motif ligand 11/Eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis |
| title_sort | serum c c motif ligand 11 eotaxin 1 may serve as a candidate biomarker for postmenopausal osteoporosis |
| topic | chemokine c-c motif chemokine 11 eotaxin1 postmenopausal osteoporosis disease severity |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581903353W.pdf |
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