The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders
Neuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions, such as oxidative and metabolic stress, protein folding or import defects, and mitochondrial DNA alteration. Cells engage in different coordinated responses to safeguard mitochondri...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=12;spage=2563;epage=2575;aulast=Patergnani |
| _version_ | 1811295788227100672 |
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| author | Simone Patergnani Giampaolo Morciano Marianna Carinci Sara Leo Paolo Pinton Alessandro Rimessi |
| author_facet | Simone Patergnani Giampaolo Morciano Marianna Carinci Sara Leo Paolo Pinton Alessandro Rimessi |
| author_sort | Simone Patergnani |
| collection | DOAJ |
| description | Neuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions, such as oxidative and metabolic stress, protein folding or import defects, and mitochondrial DNA alteration. Cells engage in different coordinated responses to safeguard mitochondrial homeostasis. In this review, we will explore the contribution of mitochondrial stress responses that are activated by the organelle to perceive these dangerous conditions, keep them under control and rescue the physiological condition of nervous cells. In the sections to come, particular attention will be dedicated to analyzing how compensatory mitochondrial hyperfusion, mitophagy, mitochondrial unfolding protein response, and apoptosis impact human neuronal diseases. Finally, we will discuss the relevance of the new concept: the “mito-inflammation”, a mitochondria-mediated inflammatory response that is recently found to cover a relevant role in the pathogenesis of diverse inflammatory-related diseases, including neuronal disorders. |
| first_indexed | 2024-04-13T05:38:44Z |
| format | Article |
| id | doaj.art-adaf8c89ffdd4951865d51184c7ff4b9 |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-04-13T05:38:44Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-adaf8c89ffdd4951865d51184c7ff4b92022-12-22T03:00:11ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-0117122563257510.4103/1673-5374.339473The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disordersSimone PatergnaniGiampaolo MorcianoMarianna CarinciSara LeoPaolo PintonAlessandro RimessiNeuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions, such as oxidative and metabolic stress, protein folding or import defects, and mitochondrial DNA alteration. Cells engage in different coordinated responses to safeguard mitochondrial homeostasis. In this review, we will explore the contribution of mitochondrial stress responses that are activated by the organelle to perceive these dangerous conditions, keep them under control and rescue the physiological condition of nervous cells. In the sections to come, particular attention will be dedicated to analyzing how compensatory mitochondrial hyperfusion, mitophagy, mitochondrial unfolding protein response, and apoptosis impact human neuronal diseases. Finally, we will discuss the relevance of the new concept: the “mito-inflammation”, a mitochondria-mediated inflammatory response that is recently found to cover a relevant role in the pathogenesis of diverse inflammatory-related diseases, including neuronal disorders.http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=12;spage=2563;epage=2575;aulast=Patergnanialzheimer’s disease; apoptosis; mitochondrial dynamics; mito-inflammation; mitophagy; multiple sclerosis; neurodegeneration; parkinson’s disease; uprmt |
| spellingShingle | Simone Patergnani Giampaolo Morciano Marianna Carinci Sara Leo Paolo Pinton Alessandro Rimessi The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders Neural Regeneration Research alzheimer’s disease; apoptosis; mitochondrial dynamics; mito-inflammation; mitophagy; multiple sclerosis; neurodegeneration; parkinson’s disease; uprmt |
| title | The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders |
| title_full | The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders |
| title_fullStr | The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders |
| title_full_unstemmed | The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders |
| title_short | The “mitochondrial stress responses”: the “Dr. Jekyll and Mr. Hyde” of neuronal disorders |
| title_sort | mitochondrial stress responses the dr jekyll and mr hyde of neuronal disorders |
| topic | alzheimer’s disease; apoptosis; mitochondrial dynamics; mito-inflammation; mitophagy; multiple sclerosis; neurodegeneration; parkinson’s disease; uprmt |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=12;spage=2563;epage=2575;aulast=Patergnani |
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