Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Heart Failure: A Comprehensive Review of Literature
Type 2 diabetes mellitus (T2DM) is highly prevalent in the modern world due to a rise in obesity. Diabetes can give rise to many secondary ailments among which heart failure is the most common. Heart failure brings about confirmatory changes in the myocardium which shifts the metabolism from gluco...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Liaquat National Hospital and Medical College
2024-04-01
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| Series: | Liaquat National Journal of Primary Care |
| Subjects: | |
| Online Access: | https://journals.lnh.edu.pk/lnjpc/pdf/89d9d8a8-970c-4a3a-bb32-d5388457e892.pdf |
| _version_ | 1797352440987648000 |
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| author | Asfandyar Khattak Hira Zaffar Khattak |
| author_facet | Asfandyar Khattak Hira Zaffar Khattak |
| author_sort | Asfandyar Khattak |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is highly prevalent in the modern world due to a rise in obesity. Diabetes can give rise to many
secondary ailments among which heart failure is the most common. Heart failure brings about confirmatory changes in the
myocardium which shifts the metabolism from glucose to fatty acid which further impairs cardiac function. Among the antidiabetic
agents, SGLT2 inhibitors such as empagliflozin and dapagliflozin have decreased heart failure exacerbations even in the absence
of diabetes. We employed search engines such as Google Scholar, MEDLINE, and Euro PMC for our article search. The keywords
such as heart failure, SGLT2 inhibitors, and diabetes were used. Duplicate studies were excluded during our analysis. According to
the literature, several theories have been put forward on the mechanisms through which SGLT2 inhibitors can work in heart failure.
Mainly they work by lowering blood pressure, improvement of cardiac energy metabolism, anti-inflammatory effect, protecting from
cardiac remodeling, diuresis, and natriuretic effects. |
| first_indexed | 2024-03-08T13:15:37Z |
| format | Article |
| id | doaj.art-adafd35913354431b44684b081755550 |
| institution | Directory Open Access Journal |
| issn | 2707-3521 2708-9134 |
| language | English |
| last_indexed | 2024-03-08T13:15:37Z |
| publishDate | 2024-04-01 |
| publisher | Liaquat National Hospital and Medical College |
| record_format | Article |
| series | Liaquat National Journal of Primary Care |
| spelling | doaj.art-adafd35913354431b44684b0817555502024-01-18T07:48:01ZengLiaquat National Hospital and Medical CollegeLiaquat National Journal of Primary Care2707-35212708-91342024-04-0161606510.37184/lnjpc.2707-3521.6.1Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Heart Failure: A Comprehensive Review of LiteratureAsfandyar Khattak0Hira Zaffar Khattak1Department of Medicine, Khyber Medical University, Peshawar, PakistanDepartment of Dentistry, Peshawar Dental College, Peshawar, PakistanType 2 diabetes mellitus (T2DM) is highly prevalent in the modern world due to a rise in obesity. Diabetes can give rise to many secondary ailments among which heart failure is the most common. Heart failure brings about confirmatory changes in the myocardium which shifts the metabolism from glucose to fatty acid which further impairs cardiac function. Among the antidiabetic agents, SGLT2 inhibitors such as empagliflozin and dapagliflozin have decreased heart failure exacerbations even in the absence of diabetes. We employed search engines such as Google Scholar, MEDLINE, and Euro PMC for our article search. The keywords such as heart failure, SGLT2 inhibitors, and diabetes were used. Duplicate studies were excluded during our analysis. According to the literature, several theories have been put forward on the mechanisms through which SGLT2 inhibitors can work in heart failure. Mainly they work by lowering blood pressure, improvement of cardiac energy metabolism, anti-inflammatory effect, protecting from cardiac remodeling, diuresis, and natriuretic effects.https://journals.lnh.edu.pk/lnjpc/pdf/89d9d8a8-970c-4a3a-bb32-d5388457e892.pdfheart failuresodium-glucose transporter 2 inhibitorsdiabetes mellitusmetabolism |
| spellingShingle | Asfandyar Khattak Hira Zaffar Khattak Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Heart Failure: A Comprehensive Review of Literature Liaquat National Journal of Primary Care heart failure sodium-glucose transporter 2 inhibitors diabetes mellitus metabolism |
| title | Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Heart Failure: A Comprehensive Review of Literature |
| title_full | Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Heart Failure: A Comprehensive Review of Literature |
| title_fullStr | Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Heart Failure: A Comprehensive Review of Literature |
| title_full_unstemmed | Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Heart Failure: A Comprehensive Review of Literature |
| title_short | Sodium-Glucose Co-Transporter 2 (SGLT-2) Inhibitors in Heart Failure: A Comprehensive Review of Literature |
| title_sort | sodium glucose co transporter 2 sglt 2 inhibitors in heart failure a comprehensive review of literature |
| topic | heart failure sodium-glucose transporter 2 inhibitors diabetes mellitus metabolism |
| url | https://journals.lnh.edu.pk/lnjpc/pdf/89d9d8a8-970c-4a3a-bb32-d5388457e892.pdf |
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