Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E
The aim of this research was to study the consequences of ω3 fatty acids (FA) administration around calving on inflammatory response and on productive performances. In this period dairy cows undergo a metabolic challenge, coming with an inflammatory-like status triggering the release of pro-inflamma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2011-10-01
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| Series: | Italian Journal of Animal Science |
| Subjects: | |
| Online Access: | http://www.aspajournal.it/index.php/ijas/article/view/2306 |
| _version_ | 1818692040748171264 |
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| author | Giuseppe Bertoni Fiorenzo Piccioli Cappelli Simone Cogrossi Paolo Grossi Erminio Trevisi |
| author_facet | Giuseppe Bertoni Fiorenzo Piccioli Cappelli Simone Cogrossi Paolo Grossi Erminio Trevisi |
| author_sort | Giuseppe Bertoni |
| collection | DOAJ |
| description | The aim of this research was to study the consequences of ω3 fatty acids (FA) administration around calving on inflammatory response and on productive performances. In this period dairy cows undergo a metabolic challenge, coming with an inflammatory-like status triggering the release of pro-inflammatory mediators (e.g. eicosanoids, cytokines). Eicosanoids synthesis may be modulated by altering the ratio of their precursors (ω3 and ω6 FA). Ten cows received 22 g/d of rumen-protected ω3 FA from -21 to +21 days from calving (OPT), while 10 (CTR) received no supplement. Cows were frequently monitored for health status, body condition score (BCS), blood (metabolic, inflammatory and FA profiles), milk yield. OPT (<em>vs</em> CTR) showed a similar milk production, a numerically smaller BCS drop, lower postpartum levels of non-esterified fatty acids (P<0.05), β-hydroxybutyric acid (P<0.1) and creatinine (P<0.05), suggesting a milder post-calving reserves mobilization. All cows underwent an inflammatory condition around calving, but OPT showed a milder response, as suggested by lower levels of bilirubin (P<0.05), and by the higher level of Liver Functionality Index (P<0.09). Plasma concentration of ω3 FA (eicosapentaenoic and docosahexaenoic acids) increased in OPT during treatment (P<0.01 vs CTR). Since ω3 FA are the main replacers of arachidonic acid in membrane phospholipids, their increased levels in plasma of OPT cows may have cut the formation of arachidonic-derivatives (pro-inflammatory mediators), countering the beginning of the inflammation. Hence, the administration of rumen-protected ω3 FA in transition period seems to attenuate the effects of subclinical inflammations and to improve the energy balance. |
| first_indexed | 2024-12-17T12:51:28Z |
| format | Article |
| id | doaj.art-adb1641cef724ca2ad7e500522d9b513 |
| institution | Directory Open Access Journal |
| issn | 1594-4077 1828-051X |
| language | English |
| last_indexed | 2024-12-17T12:51:28Z |
| publishDate | 2011-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Italian Journal of Animal Science |
| spelling | doaj.art-adb1641cef724ca2ad7e500522d9b5132022-12-21T21:47:35ZengTaylor & Francis GroupItalian Journal of Animal Science1594-40771828-051X2011-10-01104e61e6110.4081/ijas.2011.e61Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin EGiuseppe BertoniFiorenzo Piccioli CappelliSimone CogrossiPaolo GrossiErminio TrevisiThe aim of this research was to study the consequences of ω3 fatty acids (FA) administration around calving on inflammatory response and on productive performances. In this period dairy cows undergo a metabolic challenge, coming with an inflammatory-like status triggering the release of pro-inflammatory mediators (e.g. eicosanoids, cytokines). Eicosanoids synthesis may be modulated by altering the ratio of their precursors (ω3 and ω6 FA). Ten cows received 22 g/d of rumen-protected ω3 FA from -21 to +21 days from calving (OPT), while 10 (CTR) received no supplement. Cows were frequently monitored for health status, body condition score (BCS), blood (metabolic, inflammatory and FA profiles), milk yield. OPT (<em>vs</em> CTR) showed a similar milk production, a numerically smaller BCS drop, lower postpartum levels of non-esterified fatty acids (P<0.05), β-hydroxybutyric acid (P<0.1) and creatinine (P<0.05), suggesting a milder post-calving reserves mobilization. All cows underwent an inflammatory condition around calving, but OPT showed a milder response, as suggested by lower levels of bilirubin (P<0.05), and by the higher level of Liver Functionality Index (P<0.09). Plasma concentration of ω3 FA (eicosapentaenoic and docosahexaenoic acids) increased in OPT during treatment (P<0.01 vs CTR). Since ω3 FA are the main replacers of arachidonic acid in membrane phospholipids, their increased levels in plasma of OPT cows may have cut the formation of arachidonic-derivatives (pro-inflammatory mediators), countering the beginning of the inflammation. Hence, the administration of rumen-protected ω3 FA in transition period seems to attenuate the effects of subclinical inflammations and to improve the energy balance.http://www.aspajournal.it/index.php/ijas/article/view/2306Dairy cow, ω3 diet supplement, Inflammation, Plasma ω3 fatty acids |
| spellingShingle | Giuseppe Bertoni Fiorenzo Piccioli Cappelli Simone Cogrossi Paolo Grossi Erminio Trevisi Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E Italian Journal of Animal Science Dairy cow, ω3 diet supplement, Inflammation, Plasma ω3 fatty acids |
| title | Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E |
| title_full | Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E |
| title_fullStr | Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E |
| title_full_unstemmed | Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E |
| title_short | Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E |
| title_sort | attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin e |
| topic | Dairy cow, ω3 diet supplement, Inflammation, Plasma ω3 fatty acids |
| url | http://www.aspajournal.it/index.php/ijas/article/view/2306 |
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