Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice

Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice

Calcium-calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes mellitus (DM), leading to the overproduction of collagen in the myocardium. We hypothesized that CaMKII plays a role in the development of diabetic nephropathy (DN). Streptozotocin (STZ) injection into FVB wild-type m...

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Bibliographic Details
Main Authors: Alexei V. Mikhailov, Yixi Liu, Heng-Jie Cheng, Jen-Jar Lin, Che Ping Cheng
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Heliyon
Subjects:
Diabetic nephropathy
Streptozotocin
Calmodulin-dependent protein kinase II
KN-93
Mesangium
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Online Access:http://www.sciencedirect.com/science/article/pii/S2405844022029413

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http://www.sciencedirect.com/science/article/pii/S2405844022029413

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