Calmodulin-dependent protein kinase II activation promotes kidney mesangial expansion in streptozotocin-induced diabetic mice
Calcium-calmodulin-dependent protein kinase II (CaMKII) is upregulated in diabetes mellitus (DM), leading to the overproduction of collagen in the myocardium. We hypothesized that CaMKII plays a role in the development of diabetic nephropathy (DN). Streptozotocin (STZ) injection into FVB wild-type m...
Main Authors: | Alexei V. Mikhailov, Yixi Liu, Heng-Jie Cheng, Jen-Jar Lin, Che Ping Cheng |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-11-01
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Series: | Heliyon |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022029413 |
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