Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems
Natural bioactive compounds have recently emerged as a current strategy for Alzheimer’s disease treatment. Carotenoids, including astaxanthin, lycopene, lutein, fucoxanthin, crocin and others are natural pigments and antioxidants, and can be used to treat a variety of diseases, including Alzheimer’s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7652 |
| _version_ | 1797605033140813824 |
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| author | Wenjing Su Wenhao Xu Enshuo Liu Weike Su Nikolay E. Polyakov |
| author_facet | Wenjing Su Wenhao Xu Enshuo Liu Weike Su Nikolay E. Polyakov |
| author_sort | Wenjing Su |
| collection | DOAJ |
| description | Natural bioactive compounds have recently emerged as a current strategy for Alzheimer’s disease treatment. Carotenoids, including astaxanthin, lycopene, lutein, fucoxanthin, crocin and others are natural pigments and antioxidants, and can be used to treat a variety of diseases, including Alzheimer’s disease. However, carotenoids, as oil-soluble substances with additional unsaturated groups, suffer from low solubility, poor stability and poor bioavailability. Therefore, the preparation of various nano-drug delivery systems from carotenoids is a current measure to achieve efficient application of carotenoids. Different carotenoid delivery systems can improve the solubility, stability, permeability and bioavailability of carotenoids to a certain extent to achieve Alzheimer’s disease efficacy. This review summarizes recent data on different carotenoid nano-drug delivery systems for the treatment of Alzheimer’s disease, including polymer, lipid, inorganic and hybrid nano-drug delivery systems. These drug delivery systems have been shown to have a beneficial therapeutic effect on Alzheimer’s disease to a certain extent. |
| first_indexed | 2024-03-11T04:55:23Z |
| format | Article |
| id | doaj.art-adb3d4b8c0cf4e7188fde553e83e2edf |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:55:23Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-adb3d4b8c0cf4e7188fde553e83e2edf2023-11-17T19:43:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248765210.3390/ijms24087652Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery SystemsWenjing Su0Wenhao Xu1Enshuo Liu2Weike Su3Nikolay E. Polyakov4Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, ChinaInstitute of Solid State Chemistry and Mechanochemistry, 630128 Novosibirsk, RussiaNatural bioactive compounds have recently emerged as a current strategy for Alzheimer’s disease treatment. Carotenoids, including astaxanthin, lycopene, lutein, fucoxanthin, crocin and others are natural pigments and antioxidants, and can be used to treat a variety of diseases, including Alzheimer’s disease. However, carotenoids, as oil-soluble substances with additional unsaturated groups, suffer from low solubility, poor stability and poor bioavailability. Therefore, the preparation of various nano-drug delivery systems from carotenoids is a current measure to achieve efficient application of carotenoids. Different carotenoid delivery systems can improve the solubility, stability, permeability and bioavailability of carotenoids to a certain extent to achieve Alzheimer’s disease efficacy. This review summarizes recent data on different carotenoid nano-drug delivery systems for the treatment of Alzheimer’s disease, including polymer, lipid, inorganic and hybrid nano-drug delivery systems. These drug delivery systems have been shown to have a beneficial therapeutic effect on Alzheimer’s disease to a certain extent.https://www.mdpi.com/1422-0067/24/8/7652carotenoidsAlzheimer’s diseasenanosized drug delivery systems |
| spellingShingle | Wenjing Su Wenhao Xu Enshuo Liu Weike Su Nikolay E. Polyakov Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems International Journal of Molecular Sciences carotenoids Alzheimer’s disease nanosized drug delivery systems |
| title | Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems |
| title_full | Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems |
| title_fullStr | Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems |
| title_full_unstemmed | Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems |
| title_short | Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems |
| title_sort | improving the treatment effect of carotenoids on alzheimer s disease through various nano delivery systems |
| topic | carotenoids Alzheimer’s disease nanosized drug delivery systems |
| url | https://www.mdpi.com/1422-0067/24/8/7652 |
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