VWA3A-derived ependyma promoter drives increased therapeutic protein secretion into the CSF
Recombinant adeno-associated viral vectors (rAAVs) are a promising strategy to treat neurodegenerative diseases because of their ability to infect non-dividing cells and confer long-term transgene expression. Despite an ever-growing library of capsid variants, widespread delivery of AAVs in the adul...
Main Authors: | Ellie M. Carrell, Yong Hong Chen, Paul T. Ranum, Stephanie L. Coffin, Larry N. Singh, Luis Tecedor, Megan S. Keiser, Eloise Hudry, Bradley T. Hyman, Beverly L. Davidson |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2023-09-01
|
Series: | Molecular Therapy: Nucleic Acids |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253123001890 |
Similar Items
-
History of research concerning the ependyma: a view from inside the human brain
by: Marc R. Del Bigio
Published: (2024-01-01) -
Intrathecal Inflammation in Progressive Multiple Sclerosis
by: Salvatore Monaco, et al.
Published: (2020-11-01) -
Ependyma in Neurodegenerative Diseases, Radiation-Induced Brain Injury and as a Therapeutic Target for Neurotrophic Factors
by: Xin-Yu Ma, et al.
Published: (2023-04-01) -
Adherens, tight, and gap junctions in ependymal cells: A systematic review of their contribution to CSF-brain barrier
by: Riccardo Serra, et al.
Published: (2023-03-01) -
Neuroinflammation induced by intracerebroventricular injection of microbial neuraminidase
by: Pablo eGranados-Durán, et al.
Published: (2015-03-01)