The Association between IgG and Disease Severity Parameters in CF Patients
Assessing disease severity in patients with cystic fibrosis (CF) is essential when directing therapies. Serum immunoglobulin G (IgG) levels increase with disease severity. Lung clearance index (LCI) is recognized as an outcome measure for CF clinical trials. Our aim was to evaluate the correlations...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/15/3316 |
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| author | Michal Gur Yael Ben-David Moneera Hanna Anat Ilivitzki Adi Weichhendler Ronen Bar-Yoseph Yazeed Toukan Kamal Masarweh Lea Bentur |
| author_facet | Michal Gur Yael Ben-David Moneera Hanna Anat Ilivitzki Adi Weichhendler Ronen Bar-Yoseph Yazeed Toukan Kamal Masarweh Lea Bentur |
| author_sort | Michal Gur |
| collection | DOAJ |
| description | Assessing disease severity in patients with cystic fibrosis (CF) is essential when directing therapies. Serum immunoglobulin G (IgG) levels increase with disease severity. Lung clearance index (LCI) is recognized as an outcome measure for CF clinical trials. Our aim was to evaluate the correlations between IgG and disease severity markers. This was a single-center retrospective study, evaluating association between IgG and markers of severity in CF patients (including clinical characteristics, lung spirometry, LCI, clinical scores and computed tomography (CT) scores) during stable conditions. There were 69 patients, age 20.5 ± 11.6 years. Nineteen (27.5%) patients had elevated IgG. IgG correlated positively with LCI (r = 0.342, <i>p</i> = 0.005). IgG was higher in pancreatic insufficient (PI) and patients with liver disease (1504.3 ± 625.5 vs. 1229 ± 276.1 mg/dL in PI vs. PS, <i>p</i> = 0.023, and 1702.6 ± 720.3 vs. 1256.2 ± 345.5 mg/dL with vs. without liver disease, <i>p</i> = 0.001, respectively). IgG also correlated positively with CRP, CT score, and days with antibiotics in the previous year (r = 0.38, <i>p</i> = 0.003; r = 0.435, <i>p</i> = 0.001; and r = 0.361, <i>p</i> = 0.002, respectively), and negatively with FEV1% and SK score (r = −0.527, <i>p</i> < 0.001 and r = −0.613, <i>p</i> < 0.001, respectively). IgG correlated with clinical parameters, pulmonary functions, and imaging. However, this is still an auxiliary test, complementing other tests, including lung function and imaging tests. Larger multi-center longitudinal studies are warranted. |
| first_indexed | 2024-03-10T09:13:14Z |
| format | Article |
| id | doaj.art-adb4138778cd458ba47388bf517bc875 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T09:13:14Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-adb4138778cd458ba47388bf517bc8752023-11-22T05:48:59ZengMDPI AGJournal of Clinical Medicine2077-03832021-07-011015331610.3390/jcm10153316The Association between IgG and Disease Severity Parameters in CF PatientsMichal Gur0Yael Ben-David1Moneera Hanna2Anat Ilivitzki3Adi Weichhendler4Ronen Bar-Yoseph5Yazeed Toukan6Kamal Masarweh7Lea Bentur8Pediatric Pulmonary Institute and CF Center, Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa 3109601, IsraelPediatric Pulmonary Institute and CF Center, Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa 3109601, IsraelPediatric Pulmonary Institute and CF Center, Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa 3109601, IsraelRappaport Faculty of Medicine, Technion—Israel Institute of Technology, Efron St 1, Haifa 3525422, IsraelPediatric Pulmonary Institute and CF Center, Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa 3109601, IsraelPediatric Pulmonary Institute and CF Center, Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa 3109601, IsraelPediatric Pulmonary Institute and CF Center, Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa 3109601, IsraelPediatric Pulmonary Institute and CF Center, Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa 3109601, IsraelPediatric Pulmonary Institute and CF Center, Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa 3109601, IsraelAssessing disease severity in patients with cystic fibrosis (CF) is essential when directing therapies. Serum immunoglobulin G (IgG) levels increase with disease severity. Lung clearance index (LCI) is recognized as an outcome measure for CF clinical trials. Our aim was to evaluate the correlations between IgG and disease severity markers. This was a single-center retrospective study, evaluating association between IgG and markers of severity in CF patients (including clinical characteristics, lung spirometry, LCI, clinical scores and computed tomography (CT) scores) during stable conditions. There were 69 patients, age 20.5 ± 11.6 years. Nineteen (27.5%) patients had elevated IgG. IgG correlated positively with LCI (r = 0.342, <i>p</i> = 0.005). IgG was higher in pancreatic insufficient (PI) and patients with liver disease (1504.3 ± 625.5 vs. 1229 ± 276.1 mg/dL in PI vs. PS, <i>p</i> = 0.023, and 1702.6 ± 720.3 vs. 1256.2 ± 345.5 mg/dL with vs. without liver disease, <i>p</i> = 0.001, respectively). IgG also correlated positively with CRP, CT score, and days with antibiotics in the previous year (r = 0.38, <i>p</i> = 0.003; r = 0.435, <i>p</i> = 0.001; and r = 0.361, <i>p</i> = 0.002, respectively), and negatively with FEV1% and SK score (r = −0.527, <i>p</i> < 0.001 and r = −0.613, <i>p</i> < 0.001, respectively). IgG correlated with clinical parameters, pulmonary functions, and imaging. However, this is still an auxiliary test, complementing other tests, including lung function and imaging tests. Larger multi-center longitudinal studies are warranted.https://www.mdpi.com/2077-0383/10/15/3316cystic fibrosisimmunoglobulin Glung clearance indexdisease severitycomputed tomography |
| spellingShingle | Michal Gur Yael Ben-David Moneera Hanna Anat Ilivitzki Adi Weichhendler Ronen Bar-Yoseph Yazeed Toukan Kamal Masarweh Lea Bentur The Association between IgG and Disease Severity Parameters in CF Patients Journal of Clinical Medicine cystic fibrosis immunoglobulin G lung clearance index disease severity computed tomography |
| title | The Association between IgG and Disease Severity Parameters in CF Patients |
| title_full | The Association between IgG and Disease Severity Parameters in CF Patients |
| title_fullStr | The Association between IgG and Disease Severity Parameters in CF Patients |
| title_full_unstemmed | The Association between IgG and Disease Severity Parameters in CF Patients |
| title_short | The Association between IgG and Disease Severity Parameters in CF Patients |
| title_sort | association between igg and disease severity parameters in cf patients |
| topic | cystic fibrosis immunoglobulin G lung clearance index disease severity computed tomography |
| url | https://www.mdpi.com/2077-0383/10/15/3316 |
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