Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes
The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial strains screened, more than half contained cell death-inducing activity. Sev...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2010-10-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/8/10/2659/ |
| _version_ | 1811185289568190464 |
|---|---|
| author | Stein Ove Døskeland Lars Herfindal Kaarina Sivonen Matti Wahlsten Frode Selheim Linn Oftedal |
| author_facet | Stein Ove Døskeland Lars Herfindal Kaarina Sivonen Matti Wahlsten Frode Selheim Linn Oftedal |
| author_sort | Stein Ove Døskeland |
| collection | DOAJ |
| description | The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial strains screened, more than half contained cell death-inducing activity. Several strains contained activity against AML cells, but not against non-malignant cells like hepatocytes and cardiomyoblasts. The apoptotic cell death induced by the various strains could be distinguished by the role of caspase activation and sensitivity to the recently detected chemotherapy-resistance-associated prosurvival protein LEDGF/p75. One strain (M44) was particularly promising since its activity counteracted the protective effect of LEDGF/p75 overexpressed in AML cells, acted synergistically with the anthracycline anticancer drug daunorubicin in AML cells, and protected cardiomyoblasts against the toxic effect of anthracyclines. We conclude that culturable benthic marine cyanobacteria from temperate environments provide a promising and hitherto underexploited source for novel antileukemic drugs. |
| first_indexed | 2024-04-11T13:27:01Z |
| format | Article |
| id | doaj.art-adb5f20861a24c8ab8e2b7e757784cb6 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T13:27:01Z |
| publishDate | 2010-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-adb5f20861a24c8ab8e2b7e757784cb62022-12-22T04:22:01ZengMDPI AGMarine Drugs1660-33972010-10-018102659267210.3390/md8102659Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not CardiomyocytesStein Ove DøskelandLars HerfindalKaarina SivonenMatti WahlstenFrode SelheimLinn OftedalThe potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial strains screened, more than half contained cell death-inducing activity. Several strains contained activity against AML cells, but not against non-malignant cells like hepatocytes and cardiomyoblasts. The apoptotic cell death induced by the various strains could be distinguished by the role of caspase activation and sensitivity to the recently detected chemotherapy-resistance-associated prosurvival protein LEDGF/p75. One strain (M44) was particularly promising since its activity counteracted the protective effect of LEDGF/p75 overexpressed in AML cells, acted synergistically with the anthracycline anticancer drug daunorubicin in AML cells, and protected cardiomyoblasts against the toxic effect of anthracyclines. We conclude that culturable benthic marine cyanobacteria from temperate environments provide a promising and hitherto underexploited source for novel antileukemic drugs.http://www.mdpi.com/1660-3397/8/10/2659/AMLcyanobacteriaapoptosiscancerleukemia |
| spellingShingle | Stein Ove Døskeland Lars Herfindal Kaarina Sivonen Matti Wahlsten Frode Selheim Linn Oftedal Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes Marine Drugs AML cyanobacteria apoptosis cancer leukemia |
| title | Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes |
| title_full | Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes |
| title_fullStr | Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes |
| title_full_unstemmed | Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes |
| title_short | Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes |
| title_sort | marine benthic cyanobacteria contain apoptosis inducing activity synergizing with daunorubicin to kill leukemia cells but not cardiomyocytes |
| topic | AML cyanobacteria apoptosis cancer leukemia |
| url | http://www.mdpi.com/1660-3397/8/10/2659/ |
| work_keys_str_mv | AT steinovedøskeland marinebenthiccyanobacteriacontainapoptosisinducingactivitysynergizingwithdaunorubicintokillleukemiacellsbutnotcardiomyocytes AT larsherfindal marinebenthiccyanobacteriacontainapoptosisinducingactivitysynergizingwithdaunorubicintokillleukemiacellsbutnotcardiomyocytes AT kaarinasivonen marinebenthiccyanobacteriacontainapoptosisinducingactivitysynergizingwithdaunorubicintokillleukemiacellsbutnotcardiomyocytes AT mattiwahlsten marinebenthiccyanobacteriacontainapoptosisinducingactivitysynergizingwithdaunorubicintokillleukemiacellsbutnotcardiomyocytes AT frodeselheim marinebenthiccyanobacteriacontainapoptosisinducingactivitysynergizingwithdaunorubicintokillleukemiacellsbutnotcardiomyocytes AT linnoftedal marinebenthiccyanobacteriacontainapoptosisinducingactivitysynergizingwithdaunorubicintokillleukemiacellsbutnotcardiomyocytes |