Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits
Dandelion (Taraxacum officinale), an oriental herbal medicine, has been shown to favorably affect choleretic, antirheumatic and diuretin properties. Recent reports have indicated that excessive oxidative stress contributes to the development of atherosclerosislinked metabolic syndrome. The objective...
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| Format: | Article |
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MDPI AG
2010-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/11/1/67/ |
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| author | Seong-Il Lim Young Kyung Rhee Chang-Won Cho Joo Hyuk Yim Ok-Hwan Lee Ung-Kyu Choi Young-Chan Kim |
| author_facet | Seong-Il Lim Young Kyung Rhee Chang-Won Cho Joo Hyuk Yim Ok-Hwan Lee Ung-Kyu Choi Young-Chan Kim |
| author_sort | Seong-Il Lim |
| collection | DOAJ |
| description | Dandelion (Taraxacum officinale), an oriental herbal medicine, has been shown to favorably affect choleretic, antirheumatic and diuretin properties. Recent reports have indicated that excessive oxidative stress contributes to the development of atherosclerosislinked metabolic syndrome. The objective of this current study was to investigate the possible hypolipidemic and antioxidative effects of dandelion root and leaf in rabbits fed with a high-cholesterol diet. A group of twenty eight male rabbits was divided into four subgroups; a normal diet group, a high-cholesterol diet group, a high-cholesterol diet with 1% (w/w) dandelion leaf group, and a high-cholesterol diet with 1% (w/w) dandelion root group. After the treatment period, the plasma antioxidant enzymes and lipid profiles were determined. Our results show that treatment with dandelion root and leaf positively changed plasma antioxidant enzyme activities and lipid profiles in cholesterol-fed rabbits, and thus may have potential hypolipidemic and antioxidant effects. Dandelion root and leaf could protect against oxidative stress linked atherosclerosis and decrease the atherogenic index. |
| first_indexed | 2024-04-13T06:23:44Z |
| format | Article |
| id | doaj.art-adb8d237f01b41ad95eecc69d180916b |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T06:23:44Z |
| publishDate | 2010-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-adb8d237f01b41ad95eecc69d180916b2022-12-22T02:58:31ZengMDPI AGInternational Journal of Molecular Sciences1422-00672010-01-01111677810.3390/ijms11010067Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed RabbitsSeong-Il LimYoung Kyung RheeChang-Won ChoJoo Hyuk YimOk-Hwan LeeUng-Kyu ChoiYoung-Chan KimDandelion (Taraxacum officinale), an oriental herbal medicine, has been shown to favorably affect choleretic, antirheumatic and diuretin properties. Recent reports have indicated that excessive oxidative stress contributes to the development of atherosclerosislinked metabolic syndrome. The objective of this current study was to investigate the possible hypolipidemic and antioxidative effects of dandelion root and leaf in rabbits fed with a high-cholesterol diet. A group of twenty eight male rabbits was divided into four subgroups; a normal diet group, a high-cholesterol diet group, a high-cholesterol diet with 1% (w/w) dandelion leaf group, and a high-cholesterol diet with 1% (w/w) dandelion root group. After the treatment period, the plasma antioxidant enzymes and lipid profiles were determined. Our results show that treatment with dandelion root and leaf positively changed plasma antioxidant enzyme activities and lipid profiles in cholesterol-fed rabbits, and thus may have potential hypolipidemic and antioxidant effects. Dandelion root and leaf could protect against oxidative stress linked atherosclerosis and decrease the atherogenic index.http://www.mdpi.com/1422-0067/11/1/67/dandelionTaraxacum officinaleatherosclerosisantioxidant activityhypolipidemic effects |
| spellingShingle | Seong-Il Lim Young Kyung Rhee Chang-Won Cho Joo Hyuk Yim Ok-Hwan Lee Ung-Kyu Choi Young-Chan Kim Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits International Journal of Molecular Sciences dandelion Taraxacum officinale atherosclerosis antioxidant activity hypolipidemic effects |
| title | Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits |
| title_full | Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits |
| title_fullStr | Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits |
| title_full_unstemmed | Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits |
| title_short | Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits |
| title_sort | hypolipidemic and antioxidant effects of dandelion taraxacum officinale root and leaf on cholesterol fed rabbits |
| topic | dandelion Taraxacum officinale atherosclerosis antioxidant activity hypolipidemic effects |
| url | http://www.mdpi.com/1422-0067/11/1/67/ |
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