Systematic review and meta-analysis of the prognostic impact of cancer among patients with acute coronary syndrome and/or percutaneous coronary intervention
Abstract Background Patients with cancer admitted for an acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI) represent a growing and high-risk population. The influence of co-existing cancer on mortality remains unclear in such patients. We aimed to assess the impact of can...
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-020-01352-0 |
| _version_ | 1818622508497108992 |
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| author | Vincent Roule Laurine Verdier Katrien Blanchart Pierre Ardouin Adrien Lemaitre Mathieu Bignon Rémi Sabatier Joachim Alexandre Farzin Beygui |
| author_facet | Vincent Roule Laurine Verdier Katrien Blanchart Pierre Ardouin Adrien Lemaitre Mathieu Bignon Rémi Sabatier Joachim Alexandre Farzin Beygui |
| author_sort | Vincent Roule |
| collection | DOAJ |
| description | Abstract Background Patients with cancer admitted for an acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI) represent a growing and high-risk population. The influence of co-existing cancer on mortality remains unclear in such patients. We aimed to assess the impact of cancer on early and late, all-cause and cardiac mortality in the setting of ACS and/or PCI. Methods We performed a systematic review and meta-analysis of studies comparing outcomes of patients with and without a history of cancer admitted for ACS and/or PCI. Results Six studies including 294,528 ACS patients and three studies including 39,973 PCI patients were selected for our meta-analysis. Patients with cancer had increased rates of in-hospital all-cause death (RR 1.74 [1.22; 2.47]), cardiac death (RR 2.44 [1.73; 3.44]) and bleeding (RR 1.64 [1.35; 1.98]) as well as one-year all-cause death (RR 2.62 [1.2; 5.73]) and cardiac death (RR 1.89 [1.25; 2.86]) in ACS studies. Rates of long term all-cause (RR 1.96 [1.52; 2.53]) but not cardiac death were higher in cancer patients admitted for PCI. Conclusion Cancer patients represent a high-risk population both in the acute phase and at long-term after an ACS or PCI. The magnitude of the risk of mortality should however be tempered by the heterogeneity among studies. Early and long term optimal management of such patients should be promoted in clinical practice. |
| first_indexed | 2024-12-16T18:26:17Z |
| format | Article |
| id | doaj.art-adbc9267dfc24ae0b415410458b3af9f |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-16T18:26:17Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-adbc9267dfc24ae0b415410458b3af9f2022-12-21T22:21:24ZengBMCBMC Cardiovascular Disorders1471-22612020-01-012011910.1186/s12872-020-01352-0Systematic review and meta-analysis of the prognostic impact of cancer among patients with acute coronary syndrome and/or percutaneous coronary interventionVincent Roule0Laurine Verdier1Katrien Blanchart2Pierre Ardouin3Adrien Lemaitre4Mathieu Bignon5Rémi Sabatier6Joachim Alexandre7Farzin Beygui8CHU de Caen Normandie, Service de Cardiologie, Caen University HospitalCHU de Caen Normandie, Service de Cardiologie, Caen University HospitalCHU de Caen Normandie, Service de Cardiologie, Caen University HospitalCHU de Caen Normandie, Service de Cardiologie, Caen University HospitalCHU de Caen Normandie, Service de Cardiologie, Caen University HospitalCHU de Caen Normandie, Service de Cardiologie, Caen University HospitalCHU de Caen Normandie, Service de Cardiologie, Caen University HospitalNormandie Univ, UNICAEN, EA 4650 Signalisation, électrophysiologie et imagerie des lésions d’ischémie-reperfusion myocardiqueCHU de Caen Normandie, Service de Cardiologie, Caen University HospitalAbstract Background Patients with cancer admitted for an acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI) represent a growing and high-risk population. The influence of co-existing cancer on mortality remains unclear in such patients. We aimed to assess the impact of cancer on early and late, all-cause and cardiac mortality in the setting of ACS and/or PCI. Methods We performed a systematic review and meta-analysis of studies comparing outcomes of patients with and without a history of cancer admitted for ACS and/or PCI. Results Six studies including 294,528 ACS patients and three studies including 39,973 PCI patients were selected for our meta-analysis. Patients with cancer had increased rates of in-hospital all-cause death (RR 1.74 [1.22; 2.47]), cardiac death (RR 2.44 [1.73; 3.44]) and bleeding (RR 1.64 [1.35; 1.98]) as well as one-year all-cause death (RR 2.62 [1.2; 5.73]) and cardiac death (RR 1.89 [1.25; 2.86]) in ACS studies. Rates of long term all-cause (RR 1.96 [1.52; 2.53]) but not cardiac death were higher in cancer patients admitted for PCI. Conclusion Cancer patients represent a high-risk population both in the acute phase and at long-term after an ACS or PCI. The magnitude of the risk of mortality should however be tempered by the heterogeneity among studies. Early and long term optimal management of such patients should be promoted in clinical practice.https://doi.org/10.1186/s12872-020-01352-0CancerPrognosisAcute coronary syndromePercutaneous coronary intervention |
| spellingShingle | Vincent Roule Laurine Verdier Katrien Blanchart Pierre Ardouin Adrien Lemaitre Mathieu Bignon Rémi Sabatier Joachim Alexandre Farzin Beygui Systematic review and meta-analysis of the prognostic impact of cancer among patients with acute coronary syndrome and/or percutaneous coronary intervention BMC Cardiovascular Disorders Cancer Prognosis Acute coronary syndrome Percutaneous coronary intervention |
| title | Systematic review and meta-analysis of the prognostic impact of cancer among patients with acute coronary syndrome and/or percutaneous coronary intervention |
| title_full | Systematic review and meta-analysis of the prognostic impact of cancer among patients with acute coronary syndrome and/or percutaneous coronary intervention |
| title_fullStr | Systematic review and meta-analysis of the prognostic impact of cancer among patients with acute coronary syndrome and/or percutaneous coronary intervention |
| title_full_unstemmed | Systematic review and meta-analysis of the prognostic impact of cancer among patients with acute coronary syndrome and/or percutaneous coronary intervention |
| title_short | Systematic review and meta-analysis of the prognostic impact of cancer among patients with acute coronary syndrome and/or percutaneous coronary intervention |
| title_sort | systematic review and meta analysis of the prognostic impact of cancer among patients with acute coronary syndrome and or percutaneous coronary intervention |
| topic | Cancer Prognosis Acute coronary syndrome Percutaneous coronary intervention |
| url | https://doi.org/10.1186/s12872-020-01352-0 |
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