The E46K mutation modulates α-synuclein prion replication in transgenic mice

The E46K mutation modulates α-synuclein prion replication in transgenic mice

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In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration. While the E46K mutation in α-synuclein causes familial Parkinson’s disease (PD), we previously discovered that thi...

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Bibliographic Details
Main Authors: Sara A. M. Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K. Ooi, Gregory E. Merz, Man Wang, Daniel A. Mordes, Steven H. Olson, Amanda L. Woerman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714912/?tool=EBI

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