The E46K mutation modulates α-synuclein prion replication in transgenic mice

In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration. While the E46K mutation in α-synuclein causes familial Parkinson’s disease (PD), we previously discovered that thi...

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Bibliographic Details
Main Authors:	Sara A. M. Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K. Ooi, Gregory E. Merz, Man Wang, Daniel A. Mordes, Steven H. Olson, Amanda L. Woerman
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2022-12-01
Series:	PLoS Pathogens
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9714912/?tool=EBI

The E46K mutation modulates α-synuclein prion replication in transgenic mice. by Sara A M Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K Ooi, Gregory E Merz, Man Wang, Daniel A Mordes, Steven H Olson, Amanda L Woerman

Published 2022-12-01

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The E46K mutation modulates α-synuclein prion replication in transgenic mice

The E46K mutation modulates α-synuclein prion replication in transgenic mice. by Sara A M Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K Ooi, Gregory E Merz, Man Wang, Daniel A Mordes, Steven H Olson, Amanda L Woerman

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