Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and Luteolin
Skin aging processes are divided into chronological aging and premature aging. Premature aging is generally caused by free radicals, from both air pollution and photoaging. Natural compounds from plant extracts are among sources of antioxidants and anti-hyaluronidase which have the ability to preven...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Universitas Padjajaran
2019-06-01
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| Series: | Majalah Kedokteran Bandung |
| Subjects: | |
| Online Access: | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/1629 |
| _version_ | 1828783561270886400 |
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| author | Ridza Jusri Wahyu Setia Widodo Wahyu Widowati Adek Armansyah Delores Elisabeth Sormin Edy Fachrial I Nyoman Ehrich Lister |
| author_facet | Ridza Jusri Wahyu Setia Widodo Wahyu Widowati Adek Armansyah Delores Elisabeth Sormin Edy Fachrial I Nyoman Ehrich Lister |
| author_sort | Ridza Jusri |
| collection | DOAJ |
| description | Skin aging processes are divided into chronological aging and premature aging. Premature aging is generally caused by free radicals, from both air pollution and photoaging. Natural compounds from plant extracts are among sources of antioxidants and anti-hyaluronidase which have the ability to prevent antiaging. One of the potential fruits related to antioxidant and antiaging activities is Anana scomosus. A. comosus has a number of phenolic compounds with biological activities. One of the main phenolic compounds in A. comosus is luteolin. The aim of this study was to evaluate the antioxidant and antiaging potentials of Pineapple Core Extract (PCE). This study was conducted at the Biomolecular and Biomedicine Research Center, Aretha Medika Utama from August to November 2018. Analysis of antioxidants from PCE and luteolin was carried out using H2O2 scavenging activity assay. The antiaging assay was carried out through inhibition of hyaluronidase enzyme, one of the important enzymes in the aging process. Luteolin had lower IC50 value of H2O2 scavenging activity of around 24.12±3.13 μg/ml, which was better than CPE with IC50 of 304.56±3.76μg/mL. The results of hyaluronidase inhibition activity assay showed that luteolin compound had a lower IC50 value of 67.38±3.99 μg/mL when compared to PCE with an IC50 value of 161.15±1.05 μg/mL. Hence, Luteolin has higher antioxidant and anti-hyaluronidase activities than PCE |
| first_indexed | 2024-12-11T23:14:15Z |
| format | Article |
| id | doaj.art-adbdc66fd65449a194ffea9eb429658c |
| institution | Directory Open Access Journal |
| issn | 0126-074X 2338-6223 |
| language | English |
| last_indexed | 2024-12-11T23:14:15Z |
| publishDate | 2019-06-01 |
| publisher | Universitas Padjajaran |
| record_format | Article |
| series | Majalah Kedokteran Bandung |
| spelling | doaj.art-adbdc66fd65449a194ffea9eb429658c2022-12-22T00:46:36ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232019-06-01512636910.15395/mkb.v51n2.16291095Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and LuteolinRidza Jusri0Wahyu Setia Widodo1Wahyu Widowati2Adek Armansyah3Delores Elisabeth Sormin4Edy Fachrial5I Nyoman Ehrich Lister6Master in Biomedical Science, Faculty of Medicine, Universitas Prima IndoensiaBiomolecular and Biomedicine Research Center, Aretha Medika UtamaFaculty of Medicine, Maranatha Christian University, Bandung, West Java, IndonesiaFaculty of Medicine, Universitas Prima Indonesia, Medan, South Sumatera, IndonesiaFaculty of Medicine, Universitas Prima Indonesia, Medan, South Sumatera, IndonesiaFaculty of Medicine, Universitas Prima Indonesia, Medan, South Sumatera, IndonesiaFaculty of Medicine, Universitas Prima Indonesia, Medan, South Sumatera, IndonesiaSkin aging processes are divided into chronological aging and premature aging. Premature aging is generally caused by free radicals, from both air pollution and photoaging. Natural compounds from plant extracts are among sources of antioxidants and anti-hyaluronidase which have the ability to prevent antiaging. One of the potential fruits related to antioxidant and antiaging activities is Anana scomosus. A. comosus has a number of phenolic compounds with biological activities. One of the main phenolic compounds in A. comosus is luteolin. The aim of this study was to evaluate the antioxidant and antiaging potentials of Pineapple Core Extract (PCE). This study was conducted at the Biomolecular and Biomedicine Research Center, Aretha Medika Utama from August to November 2018. Analysis of antioxidants from PCE and luteolin was carried out using H2O2 scavenging activity assay. The antiaging assay was carried out through inhibition of hyaluronidase enzyme, one of the important enzymes in the aging process. Luteolin had lower IC50 value of H2O2 scavenging activity of around 24.12±3.13 μg/ml, which was better than CPE with IC50 of 304.56±3.76μg/mL. The results of hyaluronidase inhibition activity assay showed that luteolin compound had a lower IC50 value of 67.38±3.99 μg/mL when compared to PCE with an IC50 value of 161.15±1.05 μg/mL. Hence, Luteolin has higher antioxidant and anti-hyaluronidase activities than PCEhttp://journal.fk.unpad.ac.id/index.php/mkb/article/view/1629antiagin, antioxidants, anti-hyaluronidase, luteolin, pineapple core extract |
| spellingShingle | Ridza Jusri Wahyu Setia Widodo Wahyu Widowati Adek Armansyah Delores Elisabeth Sormin Edy Fachrial I Nyoman Ehrich Lister Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and Luteolin Majalah Kedokteran Bandung antiagin, antioxidants, anti-hyaluronidase, luteolin, pineapple core extract |
| title | Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and Luteolin |
| title_full | Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and Luteolin |
| title_fullStr | Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and Luteolin |
| title_full_unstemmed | Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and Luteolin |
| title_short | Comparison of Antioxidant and Anti-hyaluronidase Potentials of Pineapple Core Extract (Ananas comosus (L.) Merr.) and Luteolin |
| title_sort | comparison of antioxidant and anti hyaluronidase potentials of pineapple core extract ananas comosus l merr and luteolin |
| topic | antiagin, antioxidants, anti-hyaluronidase, luteolin, pineapple core extract |
| url | http://journal.fk.unpad.ac.id/index.php/mkb/article/view/1629 |
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