Role of Cardiac Natriuretic Peptides in Heart Structure and Function
Cardiac natriuretic peptides (NPs), atrial NP (ANP) and B-type NP (BNP) are true hormones produced and released by cardiomyocytes, exerting several systemic effects. Together with C-type NP (CNP), mainly expressed by endothelial cells, they also exert several paracrine and autocrine activities on th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14415 |
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| author | Riccardo Sarzani Massimiliano Allevi Chiara Di Pentima Paola Schiavi Francesco Spannella Federico Giulietti |
| author_facet | Riccardo Sarzani Massimiliano Allevi Chiara Di Pentima Paola Schiavi Francesco Spannella Federico Giulietti |
| author_sort | Riccardo Sarzani |
| collection | DOAJ |
| description | Cardiac natriuretic peptides (NPs), atrial NP (ANP) and B-type NP (BNP) are true hormones produced and released by cardiomyocytes, exerting several systemic effects. Together with C-type NP (CNP), mainly expressed by endothelial cells, they also exert several paracrine and autocrine activities on the heart itself, contributing to cardiovascular (CV) health. In addition to their natriuretic, vasorelaxant, metabolic and antiproliferative systemic properties, NPs prevent cardiac hypertrophy, fibrosis, arrhythmias and cardiomyopathies, counteracting the development and progression of heart failure (HF). Moreover, recent studies revealed that a protein structurally similar to NPs mainly produced by skeletal muscles and osteoblasts called musclin/osteocrin is able to interact with the NPs clearance receptor, attenuating cardiac dysfunction and myocardial fibrosis and promoting heart protection during pathological overload. This narrative review is focused on the direct activities of this molecule family on the heart, reporting both experimental and human studies that are clinically relevant for physicians. |
| first_indexed | 2024-03-09T18:15:55Z |
| format | Article |
| id | doaj.art-adbe504b2690496196c31cce1f6fdd36 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:15:55Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-adbe504b2690496196c31cce1f6fdd362023-11-24T08:43:57ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221441510.3390/ijms232214415Role of Cardiac Natriuretic Peptides in Heart Structure and FunctionRiccardo Sarzani0Massimiliano Allevi1Chiara Di Pentima2Paola Schiavi3Francesco Spannella4Federico Giulietti5Internal Medicine and Geriatrics, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Nazionale di Ricovero e Cura per Anziani (IRCCS INRCA), 60127 Ancona, ItalyInternal Medicine and Geriatrics, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Nazionale di Ricovero e Cura per Anziani (IRCCS INRCA), 60127 Ancona, ItalyInternal Medicine and Geriatrics, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Nazionale di Ricovero e Cura per Anziani (IRCCS INRCA), 60127 Ancona, ItalyInternal Medicine and Geriatrics, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Nazionale di Ricovero e Cura per Anziani (IRCCS INRCA), 60127 Ancona, ItalyInternal Medicine and Geriatrics, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Nazionale di Ricovero e Cura per Anziani (IRCCS INRCA), 60127 Ancona, ItalyInternal Medicine and Geriatrics, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto Nazionale di Ricovero e Cura per Anziani (IRCCS INRCA), 60127 Ancona, ItalyCardiac natriuretic peptides (NPs), atrial NP (ANP) and B-type NP (BNP) are true hormones produced and released by cardiomyocytes, exerting several systemic effects. Together with C-type NP (CNP), mainly expressed by endothelial cells, they also exert several paracrine and autocrine activities on the heart itself, contributing to cardiovascular (CV) health. In addition to their natriuretic, vasorelaxant, metabolic and antiproliferative systemic properties, NPs prevent cardiac hypertrophy, fibrosis, arrhythmias and cardiomyopathies, counteracting the development and progression of heart failure (HF). Moreover, recent studies revealed that a protein structurally similar to NPs mainly produced by skeletal muscles and osteoblasts called musclin/osteocrin is able to interact with the NPs clearance receptor, attenuating cardiac dysfunction and myocardial fibrosis and promoting heart protection during pathological overload. This narrative review is focused on the direct activities of this molecule family on the heart, reporting both experimental and human studies that are clinically relevant for physicians.https://www.mdpi.com/1422-0067/23/22/14415natriuretic peptidesANPBNPCNPosteocrinmusclin |
| spellingShingle | Riccardo Sarzani Massimiliano Allevi Chiara Di Pentima Paola Schiavi Francesco Spannella Federico Giulietti Role of Cardiac Natriuretic Peptides in Heart Structure and Function International Journal of Molecular Sciences natriuretic peptides ANP BNP CNP osteocrin musclin |
| title | Role of Cardiac Natriuretic Peptides in Heart Structure and Function |
| title_full | Role of Cardiac Natriuretic Peptides in Heart Structure and Function |
| title_fullStr | Role of Cardiac Natriuretic Peptides in Heart Structure and Function |
| title_full_unstemmed | Role of Cardiac Natriuretic Peptides in Heart Structure and Function |
| title_short | Role of Cardiac Natriuretic Peptides in Heart Structure and Function |
| title_sort | role of cardiac natriuretic peptides in heart structure and function |
| topic | natriuretic peptides ANP BNP CNP osteocrin musclin |
| url | https://www.mdpi.com/1422-0067/23/22/14415 |
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