Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II
Abstract The reciprocal connections between the cerebellum and the cerebrum have been suggested to simultaneously play a role in brain size increase and to support a broad array of brain functions in primates. The cerebello-cerebral system has undergone marked functionally relevant reorganization. I...
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| Format: | Article |
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Nature Portfolio
2023-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-05553-z |
| _version_ | 1797451778530213888 |
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| author | Neville Magielse Roberto Toro Vanessa Steigauf Mahta Abbaspour Simon B. Eickhoff Katja Heuer Sofie L. Valk |
| author_facet | Neville Magielse Roberto Toro Vanessa Steigauf Mahta Abbaspour Simon B. Eickhoff Katja Heuer Sofie L. Valk |
| author_sort | Neville Magielse |
| collection | DOAJ |
| description | Abstract The reciprocal connections between the cerebellum and the cerebrum have been suggested to simultaneously play a role in brain size increase and to support a broad array of brain functions in primates. The cerebello-cerebral system has undergone marked functionally relevant reorganization. In particular, the lateral cerebellar lobules crura I-II (the ansiform) have been suggested to be expanded in hominoids. Here, we manually segmented 63 cerebella (34 primate species; 9 infraorders) and 30 ansiforms (13 species; 8 infraorders) to understand how their volumes have evolved over the primate lineage. Together, our analyses support proportional cerebellar-cerebral scaling, whereas ansiforms have expanded faster than the cerebellum and cerebrum. We did not find different scaling between strepsirrhines and haplorhines, nor between apes and non-apes. In sum, our study shows primate-general structural reorganization of the ansiform, relative to the cerebello-cerebral system, which is relevant for specialized brain functions in an evolutionary context. |
| first_indexed | 2024-03-09T14:59:19Z |
| format | Article |
| id | doaj.art-adc447d0d62a4d48b789af92a3c04978 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-03-09T14:59:19Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-adc447d0d62a4d48b789af92a3c049782023-11-26T14:00:11ZengNature PortfolioCommunications Biology2399-36422023-11-016111710.1038/s42003-023-05553-zPhylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-IINeville Magielse0Roberto Toro1Vanessa Steigauf2Mahta Abbaspour3Simon B. Eickhoff4Katja Heuer5Sofie L. Valk6Institute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Wilhelm-Johnen-StraßeInstitut Pasteur, Unité de Neuroanatomie Appliquée et Théorique, Université Paris CitéDepartment of Biology, Northern Michigan UniversityBerlin School of Mind and Brain, Humboldt-Universität zu BerlinInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Wilhelm-Johnen-StraßeInstitut Pasteur, Unité de Neuroanatomie Appliquée et Théorique, Université Paris CitéInstitute of Neuroscience and Medicine, Brain and Behaviour (INM-7), Research Center Jülich, Wilhelm-Johnen-StraßeAbstract The reciprocal connections between the cerebellum and the cerebrum have been suggested to simultaneously play a role in brain size increase and to support a broad array of brain functions in primates. The cerebello-cerebral system has undergone marked functionally relevant reorganization. In particular, the lateral cerebellar lobules crura I-II (the ansiform) have been suggested to be expanded in hominoids. Here, we manually segmented 63 cerebella (34 primate species; 9 infraorders) and 30 ansiforms (13 species; 8 infraorders) to understand how their volumes have evolved over the primate lineage. Together, our analyses support proportional cerebellar-cerebral scaling, whereas ansiforms have expanded faster than the cerebellum and cerebrum. We did not find different scaling between strepsirrhines and haplorhines, nor between apes and non-apes. In sum, our study shows primate-general structural reorganization of the ansiform, relative to the cerebello-cerebral system, which is relevant for specialized brain functions in an evolutionary context.https://doi.org/10.1038/s42003-023-05553-z |
| spellingShingle | Neville Magielse Roberto Toro Vanessa Steigauf Mahta Abbaspour Simon B. Eickhoff Katja Heuer Sofie L. Valk Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II Communications Biology |
| title | Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II |
| title_full | Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II |
| title_fullStr | Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II |
| title_full_unstemmed | Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II |
| title_short | Phylogenetic comparative analysis of the cerebello-cerebral system in 34 species highlights primate-general expansion of cerebellar crura I-II |
| title_sort | phylogenetic comparative analysis of the cerebello cerebral system in 34 species highlights primate general expansion of cerebellar crura i ii |
| url | https://doi.org/10.1038/s42003-023-05553-z |
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