Vitamin D and immune response: implications for prostate cancer in African Americans
Prostate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still unclear. Epidemiologic studies have shown that vitamin D deficiency is associ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00053/full |
| _version_ | 1818130906590740480 |
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| author | Ken eBatai Adam eMurphy Larisa eNonn Rick eKittles |
| author_facet | Ken eBatai Adam eMurphy Larisa eNonn Rick eKittles |
| author_sort | Ken eBatai |
| collection | DOAJ |
| description | Prostate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still unclear. Epidemiologic studies have shown that vitamin D deficiency is associated with advanced stage, and higher tumor grade and mortality, while its association with overall PCa risk is inconsistent. Vitamin D deficiency is also more common in AAs than EAs, and the difference in serum vitamin D levels may help explain the PCa disparities. However, the role of vitamin D in aggressive PCa in AAs is not well explored. Studies demonstrated that the active form of vitamin D, 1,25-dihydroxyvitamin D, has anti-inflammatory effects by mediating immune-related gene expression in prostate tissue. Inflammation also plays an important role in PCa pathogenesis and progression, and expression of immune-related genes in PCa tissues differs significantly between AAs and EAs. Unfortunately, the evidence linking vitamin D and immune response in relation to PCa is still scarce. This relationship should be further explored at a genomic level in AA populations that are at high risk for vitamin D deficiency and fatal PCa. |
| first_indexed | 2024-12-11T08:12:29Z |
| format | Article |
| id | doaj.art-adc471fe015a4cbbbf8a6a2003e6fb6e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T08:12:29Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-adc471fe015a4cbbbf8a6a2003e6fb6e2022-12-22T01:14:51ZengFrontiers Media S.A.Frontiers in Immunology1664-32242016-02-01710.3389/fimmu.2016.00053180347Vitamin D and immune response: implications for prostate cancer in African AmericansKen eBatai0Adam eMurphy1Larisa eNonn2Rick eKittles3University of ArizonaNorthwestern UniversityUniversity of Illinois at ChicagoUniversity of ArizonaProstate cancer (PCa) is the most common cancer among men in the U.S. African American (AA) men have a higher incidence and mortality rate compared to European American (EA) men, but the cause of PCa disparities is still unclear. Epidemiologic studies have shown that vitamin D deficiency is associated with advanced stage, and higher tumor grade and mortality, while its association with overall PCa risk is inconsistent. Vitamin D deficiency is also more common in AAs than EAs, and the difference in serum vitamin D levels may help explain the PCa disparities. However, the role of vitamin D in aggressive PCa in AAs is not well explored. Studies demonstrated that the active form of vitamin D, 1,25-dihydroxyvitamin D, has anti-inflammatory effects by mediating immune-related gene expression in prostate tissue. Inflammation also plays an important role in PCa pathogenesis and progression, and expression of immune-related genes in PCa tissues differs significantly between AAs and EAs. Unfortunately, the evidence linking vitamin D and immune response in relation to PCa is still scarce. This relationship should be further explored at a genomic level in AA populations that are at high risk for vitamin D deficiency and fatal PCa.http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00053/fullAfrican AmericansInflammationVitamin Dprostate cancerHealth DisparitiesCOX-2 |
| spellingShingle | Ken eBatai Adam eMurphy Larisa eNonn Rick eKittles Vitamin D and immune response: implications for prostate cancer in African Americans Frontiers in Immunology African Americans Inflammation Vitamin D prostate cancer Health Disparities COX-2 |
| title | Vitamin D and immune response: implications for prostate cancer in African Americans |
| title_full | Vitamin D and immune response: implications for prostate cancer in African Americans |
| title_fullStr | Vitamin D and immune response: implications for prostate cancer in African Americans |
| title_full_unstemmed | Vitamin D and immune response: implications for prostate cancer in African Americans |
| title_short | Vitamin D and immune response: implications for prostate cancer in African Americans |
| title_sort | vitamin d and immune response implications for prostate cancer in african americans |
| topic | African Americans Inflammation Vitamin D prostate cancer Health Disparities COX-2 |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00053/full |
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