Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis Patients
Background Multiple Sclerosis (MS) is a demyelinating disease of central nervous system with an unknown etiology. Beta-Interferon is now widely used for treatment of MS which is believed to slow down the disease progression. This study was designed to compare the side-effects of Avonex and t...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2009-05-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/196 |
| _version_ | 1797760923183611904 |
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| author | Masoud Etemadifar Amir Hadi Maghzi Amir Hoseinzadeh |
| author_facet | Masoud Etemadifar Amir Hadi Maghzi Amir Hoseinzadeh |
| author_sort | Masoud Etemadifar |
| collection | DOAJ |
| description | Background
Multiple Sclerosis (MS) is a demyelinating disease of central nervous system with an unknown etiology. Beta-Interferon is now widely used for treatment of MS which is believed to slow down the disease progression. This study was designed to compare the side-effects of Avonex and the Iranian 1-a Beta-Interferon, Cinnovex, which are biosimilars.
Methods
This was a clinical trial study in which fifty one MS patients were recruited from the neurology departments of Al-Zahra and Shariati hospitals in 2007. Twenty one patients were receiving Avonex and thirty patients were receiving Cinnovex. These patients were followed for 3 months to compare the side-effects of the drugs between two groups.
Findings
The most prevalent side effect observed was influenza like symptoms in all patients receiving Avonex and in 83.3% of patients receiving Cinnovex. There were no cases of seizure or diarrhea in any of groups. In this study, there were no significant differences between two groups in respect to experienced side-effects.
Conclusion
This study with a short duration follow-up of 3 months demonstrated no significant differences between the two groups in case of experienced side-effects.
Key words: CinnoVex, Avonex, side effects, treatment, Interferon beta 1-a, multiple sclerosis |
| first_indexed | 2024-03-12T19:05:31Z |
| format | Article |
| id | doaj.art-adc550d2f54f4c50bc7fc2973b928491 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T19:05:31Z |
| publishDate | 2009-05-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-adc550d2f54f4c50bc7fc2973b9284912023-08-02T06:18:52ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2009-05-01279393101189Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis PatientsMasoud Etemadifar0Amir Hadi Maghzi1Amir Hoseinzadeh2Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, IsfahanMedical Student, School of Medicine, Isfahan University of Medical Sciences, IsfahanAssistant Professor, Department of Neurology, School of Medicine, Najaf Abad Azad University, IsfahanBackground Multiple Sclerosis (MS) is a demyelinating disease of central nervous system with an unknown etiology. Beta-Interferon is now widely used for treatment of MS which is believed to slow down the disease progression. This study was designed to compare the side-effects of Avonex and the Iranian 1-a Beta-Interferon, Cinnovex, which are biosimilars. Methods This was a clinical trial study in which fifty one MS patients were recruited from the neurology departments of Al-Zahra and Shariati hospitals in 2007. Twenty one patients were receiving Avonex and thirty patients were receiving Cinnovex. These patients were followed for 3 months to compare the side-effects of the drugs between two groups. Findings The most prevalent side effect observed was influenza like symptoms in all patients receiving Avonex and in 83.3% of patients receiving Cinnovex. There were no cases of seizure or diarrhea in any of groups. In this study, there were no significant differences between two groups in respect to experienced side-effects. Conclusion This study with a short duration follow-up of 3 months demonstrated no significant differences between the two groups in case of experienced side-effects. Key words: CinnoVex, Avonex, side effects, treatment, Interferon beta 1-a, multiple sclerosishttp://jims.mui.ac.ir/index.php/jims/article/view/196 |
| spellingShingle | Masoud Etemadifar Amir Hadi Maghzi Amir Hoseinzadeh Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis Patients مجله دانشکده پزشکی اصفهان |
| title | Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis Patients |
| title_full | Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis Patients |
| title_fullStr | Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis Patients |
| title_full_unstemmed | Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis Patients |
| title_short | Comparing Side effects of CinnoVex with Avonex in Relapsing Remitting Multiple Sclerosis Patients |
| title_sort | comparing side effects of cinnovex with avonex in relapsing remitting multiple sclerosis patients |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/196 |
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